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Endothelial

Dekker A, Reitsma K, Beugeling T, Bant]es A, Fei]en J and van Aken W G 1991 Adhesion of endothelial-oells and adsorption of serum-proteins on gas plasma-treated polytetrafluoroethylene S/omaferfa/s 12 130-8... [Pg.2640]

Three years later Robert F Furchgott discov ered that the relaxing of smooth muscles such as blood vessel walls was stimulated by an unknown substance produced in the lining of the blood vessels (the endothelium) He called this substance the endothelium-dependent relaxing factor or EDRF and in 1986 showed that EDRF was NO Louis J Ignarro reached the same conclusion at about the same time Further support was provided by Salvador Moncada who showed that endothelial cells did in deed produce NO and that the l arginine to l citrulline conversion was responsible... [Pg.1149]

These interactions involve adhesion proteins called selectins, which are found both on the rolling leukocytes and on the endothelial cells of the vascular walls. Selectins have a characteristic domain structure, consisting of an N-terminal extracellular lectin domain, a single epidermal growth factor (EGR) domain, a series of two to nine short consensus repeat (SCR) domains, a single transmembrane segment, and a short cytoplasmic domain. Lectin domains, first characterized in plants, bind carbohydrates... [Pg.283]

These small-molecule thiols serve to transfer NO from erythrocytes to endothelial receptors, where it acts to relax vascular tension. NO itself is a reactive free-radical compound whose biological half-life is very short (1-5 sec). S-nitrosoglutathione has a half-life of several hours. [Pg.493]

Human adrenomedullin is a 52-amino acid peptide belonging to the calcitonin/calcitonin gene-related peptide (CGRP)/amylin peptide family. It is synthesized mainly in endothelial cells and elicits vasodilation. [Pg.50]

The a subunits, for which two isoforms exist in mammals (al, a2), contain conventional protein serine/threonine kinase domains at the N-terminus, with a threonine residue in the activation loop (Thr-172) that must be phosphorylated by upstream kinases (see below) before the kinase is active. The kinase domain is followed by an autoinhibitory domain, whose effect is somehow relieved by interaction with the other subunits. The C-terminal domain of the a subunit is required for the formation of a complex with the C-terminal domain of the (3 subunit, which in turn mediates binding to the y subunit. The al and a2 catalytic subunit isoforms are widely distributed, although a2 is most abundant in muscle and may be absent in cells of the endothelial/hemopoietic lineage. [Pg.69]

AMPK can also be activated by a Ca2+-mediated pathway involving phosphorylation at Thr-172 by the Ca2+/calmodulin-dependent protein kinase, CaMKK 3. CaMKKa and CaMKK 3 were discovered as the upstream kinase for the calmodulin-dependent protein kinases-1 and -IV they both activate AMPK in a Ca2+/ calmodulin-dependent manner in cell-free assays, although CaMKK 3 appears to much more active against AMPK in intact cells. Expression of CaMKKa and CaMKK(3 primarily occurs in neural tissues, but CaMKKp is also expressed in some other cell types. Thus, the Ca2+-mediated pathway for AMPK activation has now been shown to occur in response to depolarization in rat neuronal tissue, in response to thrombin (acting via a Gq-coupled receptor) in endothelial cells, and in response to activation of the T cell receptor in T cells. [Pg.71]

Vascular Endothelial Growth Inhibitor (Protein sharing homology with TNF-a) Inhibits EC proliferation... [Pg.85]

Thrombospondins Inhibits EC proliferation, migration and induces EC apoptosis by binding to endothelial CD36... [Pg.85]

Marimastat Metalloproteinase inhibitor, inhibits endothelial cell invasion... [Pg.85]

Vascular gene therapy Transfer of dominant-negative receptors or suicide genes under the control of angiogenic endothelial cell specific promoters... [Pg.85]

Systematic screening experiments have identified more than 100 synthetic compounds with potent antiangiogenic activity. The mode of action for most of these molecules is not well understood, but some of the 40 compounds are well advanced in clinical trials (Table 3). The first substance to have entered clinical trials was the Fumagillin-derivative AGM 1470. Fumagillin is an antibiotic which inhibits bFGF- and PDGF-induced endothelial cell proliferation. The mechanism of action of AGM 1470 is poorly understood, but it was shown that it binds and inhibits the metalloprotease methionine aminopeptidase (MetAp-2). [Pg.87]

Protein C is a vitamin K-dependent natural anticoagulant activated by thrombin to form APC in the presence of the endothelial receptor, TM. APC proteolyzes factors Va and Villa, thus downregulating thrombin generation. APC may also have anti-inflammatory... [Pg.110]


See other pages where Endothelial is mentioned: [Pg.454]    [Pg.2640]    [Pg.123]    [Pg.205]    [Pg.284]    [Pg.283]    [Pg.283]    [Pg.493]    [Pg.493]    [Pg.185]    [Pg.5]    [Pg.10]    [Pg.10]    [Pg.38]    [Pg.40]    [Pg.40]    [Pg.41]    [Pg.80]    [Pg.81]    [Pg.82]    [Pg.83]    [Pg.83]    [Pg.83]    [Pg.83]    [Pg.84]    [Pg.84]    [Pg.85]    [Pg.86]    [Pg.86]    [Pg.87]    [Pg.87]    [Pg.88]    [Pg.88]    [Pg.89]    [Pg.95]    [Pg.108]   
See also in sourсe #XX -- [ Pg.705 ]

See also in sourсe #XX -- [ Pg.402 , Pg.403 , Pg.404 , Pg.407 , Pg.409 , Pg.420 , Pg.421 , Pg.433 , Pg.435 , Pg.441 , Pg.448 ]

See also in sourсe #XX -- [ Pg.226 , Pg.227 , Pg.228 , Pg.229 , Pg.230 , Pg.231 , Pg.232 , Pg.236 , Pg.239 , Pg.241 , Pg.242 , Pg.243 , Pg.248 ]




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2 HAEC (Human aortic endothelial

Adhesion to endothelial cell monolayer

Adhesion to endothelial cells

Albumin transfer across endothelial

Albumin transfer across endothelial monolayers

Angiogenesis endothelial cells

Angiogenesis endothelial growth factor

Angiogenic mechanisms endothelial cell proliferation

Anti-human vascular endothelial growth factor

Antibodies anti endothelial cell binding

Antibodies endothelial cell targeting

Antiproliferative effect endothelial cells

Apoptosis vascular endothelial cells

Arachidonic acid endothelial cell damage

Astrocyte-endothelial interactions

Atherogenesis endothelial cell function

Atherogenesis endothelial dysfunction

Atherosclerosis Endothelial injuries

Autologous endothelial cells

Avastin vascular endothelial growth factor

BBB endothelial cells

Blood capillaries endothelial lining

Blood outgrowth endothelial cells

Blood-brain barrier endothelial cells

Bovine aortic endothelial cells

Bovine aortic endothelial cells (BAECs

Bovine aortic endothelial cells BAEC)

Bovine brain microvascular endothelial cells

Bovine corneal endothelial cells

Bovine coronary artery endothelial cells

Bovine endothelial

Bovine endothelial cell

Bovine microvascular endothelial cells

Bovine pulmonary aortic endothelial cells

Brain Endothelial permeability

Brain capillary endothelial cell culture

Brain capillary endothelial cells

Brain endothelial cells

Brain microvascular endothelial cells

Brain microvessel endothelial

Brain microvessel endothelial cells

CXCR4 receptor endothelial cells

Cadmium endothelial cell damage

Cadmium endothelial damage

Cancer, treatment using vascular endothelial growth factor

Capillary endothelial

Capillary endothelial cells

Cell , biological endothelial

Cell monolayers brain microvessel endothelial

Cell, animal endothelial cells

Cerebral microvessel endothelial cells

Characterization of endothelial cells

Circulating endothelial precursor

Circulating endothelial progenitor cells

Coagulation endothelial cell products

Contribution of Endothelial and Neuronal NOS Isoforms

Corneal endothelial protection

Dermal microvascular endothelial cells

Drugs Inhibiting Endothelial Activation

ENOS expression Endothelial nitric oxide synthase

Effects on Endothelial Function

Embryo, mouse endothelial cells

Endocrine gland-derived vascular endothelial growth factor

Endocytosis sinusoidal endothelial cells

Endothelial Cell Function and Cardiopulmonary Bypass

Endothelial Cell Sources

Endothelial Cell Surface Heparan Sulphate,

Endothelial Lipase

Endothelial Lipase A Novel Drug Target for HDL and Atherosclerosis

Endothelial Lipase as a Potential Pharmacologic Target

Endothelial NADPH oxidase

Endothelial NO synthase

Endothelial NOS

Endothelial Protection

Endothelial Tissue Engineering

Endothelial Tumors

Endothelial activation

Endothelial activation inhibition

Endothelial angiogenic vasculature

Endothelial antagonists

Endothelial antagonists characterized

Endothelial antagonists syntheses

Endothelial barrier

Endothelial brain

Endothelial brain endothelium

Endothelial ceh

Endothelial cell barrier

Endothelial cell characterization assays

Endothelial cell colonization

Endothelial cell contact

Endothelial cell contact modulation

Endothelial cell contractile protein

Endothelial cell damage

Endothelial cell growth factors

Endothelial cell interactions

Endothelial cell interactions Bovine aortic

Endothelial cell interactions Cytokine-mediation

Endothelial cell interactions From liver

Endothelial cell interactions From lung

Endothelial cell interactions Phenotypic modulation

Endothelial cell interactions cells

Endothelial cell interactions enzyme activity

Endothelial cell interactions molecules

Endothelial cell interactions monolayers

Endothelial cell interactions preparation

Endothelial cell interactions surface

Endothelial cell membrane

Endothelial cell monolayer barrier

Endothelial cell monolayer permeability

Endothelial cell neoplasms

Endothelial cell pinch

Endothelial cell protein C receptor

Endothelial cell receptors

Endothelial cell repair

Endothelial cell seeded

Endothelial cell specific promoter

Endothelial cell swelling

Endothelial cell viability

Endothelial cell-derived relaxing factor. See

Endothelial cell-derived relaxing factor. See Nitric oxide

Endothelial cells

Endothelial cells HUVEC

Endothelial cells apoptosis, inducing

Endothelial cells atherosclerosis

Endothelial cells binding assay

Endothelial cells cell culture

Endothelial cells chemokines, binding

Endothelial cells cholesterol oxides

Endothelial cells control

Endothelial cells cyclosporine nephrotoxicity

Endothelial cells dementia

Endothelial cells diabetes mellitus

Endothelial cells donors

Endothelial cells dysfunction

Endothelial cells function

Endothelial cells functional consequences

Endothelial cells gene transfer

Endothelial cells homocysteine

Endothelial cells injury

Endothelial cells integrins

Endothelial cells lipid oxidation products

Endothelial cells migration and proliferation

Endothelial cells niacin

Endothelial cells nitric oxide formation

Endothelial cells oxLDL

Endothelial cells oxysterols

Endothelial cells proteolytic activity

Endothelial cells regulation

Endothelial cells release

Endothelial cells roles

Endothelial cells selectins

Endothelial cells sinusoid

Endothelial cells stents

Endothelial cells synthesize and release substances that cause vasoconstriction or vasorelaxation

Endothelial cells vascular, functions

Endothelial cells, autocrine production

Endothelial cells, brain capillary microvessel

Endothelial cells, cerebral

Endothelial cells, glomerular capillary wall

Endothelial cells, isolated

Endothelial cells, membrane proteins

Endothelial cells, peroxynitrite production

Endothelial cells, plasminogen activation

Endothelial cells, protein-mediated cell

Endothelial cells, sensitivity

Endothelial damage

Endothelial derived relaxing factor

Endothelial differentiation gene

Endothelial differentiation gene (EDG

Endothelial dysfunction

Endothelial dystrophy, Fuchs

Endothelial function

Endothelial function and

Endothelial growth factors

Endothelial independence

Endothelial integrin

Endothelial layer

Endothelial layer barrier

Endothelial leucocyte adhesion

Endothelial leucocyte adhesion molecule-1 (ELAM

Endothelial leukocyte adhesion

Endothelial leukocyte adhesion expression

Endothelial leukocyte adhesion molecule

Endothelial leukocyte adhesion molecule-1 (ELAM

Endothelial lipoprotein lipase

Endothelial markers

Endothelial microparticles

Endothelial microparticles release

Endothelial nitric oxide synthase

Endothelial nitric oxide synthase (eNOS

Endothelial nitric oxide synthase angiogenesis, role

Endothelial nitric oxide synthase determination

Endothelial nitric oxide synthase phosphorylation

Endothelial nitric oxide synthase vascular pathology

Endothelial nitric-oxygen synthase

Endothelial nitric-oxygen synthase endothelium

Endothelial permeability

Endothelial plaque stability

Endothelial progenitor cells

Endothelial relaxing factor

Endothelial sources

Endothelial surface

Endothelial tumor vasculature

Endothelial xanthine oxidoreductase

Endothelial, cultured

Endothelial/endothelium

Endothelialitis

Endothelialization

Endothelialization

Endothelialization surface-engineered

Endothelium, endothelial cells

Enzymatic Activity and Effects on Cellular Lipid Metabolism of Endothelial Lipase

Eosinophil-endothelial interaction

Experimental Pharmacology of Pulmonary Endothelial Cells

Extravasation Vascular endothelial cell

Extravasation endothelial cells

Formation endothelial

Free-Radical Generation and Augmentation of Antioxidant Enzyme Activity in Vascular Endothelial Cells by Garlic

Functional Assays with Endothelial Cells

Functional Consequences of Endothelial NO Formation

General Considerations and Practical Directions for Endothelial Cell Targeting Research

Genes endothelial constitutive nitric-oxide

Glomerular microvascular endothelial cells

HUVECs (human umbilical vein endothelial

HUVECs endothelial cells

Hepatic sinusoidal endothelial cells

High endothelial venules

High venule endothelial cells

Human Endothelial Lipase Gene

Human aortic endothelial cell

Human aortic endothelial cells HAECs)

Human aortic endothelial cells studies with

Human coronary artery endothelial cell

Human dermal microvascular endothelial

Human dermal microvascular endothelial cells, culture

Human microvascular endothelial cell

Human placental endothelial cells

Human saphenous vein endothelial cells

Human umbilical cord endothelial cells

Human umbilical endothelial cells

Human umbilical vein endothelial

Human umbilical vein endothelial HUVEC)

Human umbilical vein endothelial cells

Human umbilical vein endothelial cells HUVEC)

Human umbilical vein endothelial cells HUVECs)

Human vascular endothelial growth

Human vascular endothelial growth factor

Hydrogen peroxide endothelial cell damage

Hypertrophied endothelial cells

Immortalized Human Cerebromicrovascular Endothelial Cells

Lamellar endothelial keratoplasty

Liposomes endothelial cells

Liver endothelial cells

Liver endothelialitis

Liver sinusoidal endothelial cells

Localization of Vascular Endothelial Growth Factor

Lucentis, vascular endothelial growth

Lucentis, vascular endothelial growth factor

Lung disease endothelial cells

Lung endothelial cells

Lymphangiogenesis vascular endothelial growth factor

Lymphatic endothelial cells

Lymphatic vessel endothelial HA receptor

Microcapillary endothelial cells

Microvascular endothelial cell preparatio

Microvascular endothelial cells

Microvessel endothelial

Monoclonal antibodies vascular endothelial growth factor

Monocyte-endothelial interactions induction

Mouse brain capillary endothelial cell line

Neutrophils adhesion to endothelial cells

Nitric endothelial

Nitric-oxide synthases endothelial

Pathophysiology vascular endothelial mechanisms

Phenotypic modulation of endothelial cell

Physiology of Endothelial Lipase

Platelet-derived endothelial cell growth factor

Platelet-derived endothelial growth factor

Platelet-endothelial cell adhesion

Platelet-endothelial cell adhesion molecule

Platelet-endothelial cell adhesion molecule PECAM

Porcine brain capillary endothelial cells

Porcine brain microvascular endothelial cells

Porcine brain microvessel endothelial cells

Porcine microvascular endothelial cell

Primary Cultures of Brain Capillary Endothelial Cells

Promoters vascular endothelial growth factor receptors

Protection, endothelial damage

Protein tyrosine kinases vascular endothelial growth factor

Pulmonary artery endothelial cells

Pulmonary artery endothelial cells PAEC)

Pulmonary artery endothelial cells bovine

Pulmonary endothelial cells

Rabbit aortic endothelial cells

Rat brain microvascular endothelial cells

Rat retinal vascular endothelial cells

Re-endothelialization

Regulation of Endothelial Lipase Expression

Relaxation endothelial-derived relaxing factor

Reticulo-endothelial system

Reticulo-endothelial system (RES

Reticulo-endothelial system organs

Reticulum-endothelial system

Shear Stress-Dependent Endothelial NO Release

Shear stress, endothelial cell response

Sinus endothelial cells

Sinusoidal endothelial cells

Targeting Drugs to the Endothelial Cell

Thrombosis endothelial cell products

Tissue Expression of Endothelial Lipase and Its Implications

Titanium endothelial cells

Transcytosis capillary endothelial cells

Transport endothelial cell wall

VEGF (vascular endothelial growth

VEGFR (vascular endothelial growth

VEGFR-2, Vascular endothelial growth factor

Vascular endothelial -cadherin

Vascular endothelial cell growth

Vascular endothelial cell growth factor

Vascular endothelial cell growth factor VEGF)

Vascular endothelial cell preparation

Vascular endothelial cells

Vascular endothelial damage

Vascular endothelial growth

Vascular endothelial growth factor

Vascular endothelial growth factor , inhibition

Vascular endothelial growth factor VEGE)

Vascular endothelial growth factor VEGF)

Vascular endothelial growth factor and angiogenesis

Vascular endothelial growth factor angiogenesis regulator

Vascular endothelial growth factor angiogenesis role

Vascular endothelial growth factor antagonist

Vascular endothelial growth factor binding

Vascular endothelial growth factor characterized

Vascular endothelial growth factor estrogens

Vascular endothelial growth factor expression

Vascular endothelial growth factor family

Vascular endothelial growth factor function

Vascular endothelial growth factor gene delivery

Vascular endothelial growth factor gene expression

Vascular endothelial growth factor inhibitors

Vascular endothelial growth factor interaction

Vascular endothelial growth factor processing

Vascular endothelial growth factor receptor

Vascular endothelial growth factor receptor 2 (VEGFR

Vascular endothelial growth factor receptor VEGFR) inhibitors

Vascular endothelial growth factor receptor inhibitors

Vascular endothelial growth factor therapy study

Vascular endothelial growth factor tumor blood vessels

Vascular endothelial growth factor tyrosine kinase inhibitors

Vascular endothelial growth factor, gene

Vascular endothelial growth factor, gene therapy

Vascular endothelial growth factors VEGFs)

Vascular endothelial growth factors adverse effects

Vascular endothelial growth factors angiogenesis

Vascular endothelial growth factors angiogenesis therapy

Vascular endothelial growth factors clinical trials

Vascular endothelial growth factors myocardial angiogenesis

Vascular endothelial growth factors promoting angiogenesis

Vascular endothelial growth factors systemic effects

Vascular endothelial protein tyrosine

Vascular endothelial protein tyrosine phosphatase

Vascular endothelial tissue peptidases

Vascular system capillary endothelial cells

Viral vectors endothelial cells

Worm endothelial cells

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