VEGFR-2, Vascular endothelial growth factor

VEGFR Vascular endothelial growth factor receptor... 

STAT-3 Signal transducer and activator of transcription-3 VEGFR Vascular endothelial growth factor receptor... 

Optimization of the large (MW = 512), lipophilic (clogP = 7.6), and very potent (Kj = 0.22 nM) Vascular Endothelial Growth Factor Receptor Tyrosine Kinase (VEGFR TK) inhibitor 8 (LLE = 2.1) to produce the development candidate axitinib (9) was recently reported [17]. 

Epidermal growth factor receptor (EGFR) Fibroblast growth factor receptor (FGFR) Vascular endothelial growth factor receptor (VEGFR)... 

Compound 57 has been identified as a vascular endothelial growth factor receptor-2 (VEGFR-2) kinase inhibitor of interest for the treatment of cancer <20030PD676>. 

Eskens FA et al (2006) The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors a review. Eur J Cancer 42 3127-3139... 

Joukov, V., Pajusola, K., Kaipainen, A., Chilov, D., Lahtinen, I., et al. 1996. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J. 15 290-298. 

Paavonen K, Mandelin J, Partanen T, Jussila L, Li TF, Ristimaki A, et al. Vascular endothelial growth factors C and D and their VEGFR-2 and 3 receptors in blood and lymphatic vessels in healthy and arthritic synovium. J Rheumatol 2002 29 39-45. 

Cai J, Jiang WG, Ahmed A, Boulton M. Vascular endothelial growth factor-induced endothelial cell proliferation is regulated by interaction between VEGFR-2, SH-PTP1 and eNOS. Microvasc Res 2006 71 20-31. 

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