Endothelial cell contact modulation

Since, protein adsorption is the first and foremost step when a biomaterial comes in contact with serum, a number of studies have been performed to modify CS for favorable protein adsorption and subsequent cellular behavior in vitro. Chung et al. photochemically grafted adhesive peptides onto the surface of CS and found that the protein-adsorbed CS promotes the adhesion and proliferation of human endothelial cells [76], Recently, bovine serum albumin (BSA) protein was adsorbed onto the surface of CS functionalized with different nanostructured carbon (graphene oxide (GO) and carbon nanohoms). The adsorption of BSA on CS was found to favorably modulate the response of osteoblasts cells, as seen by the attachment and spreading of cells to form an ECM on the protein adsorbed substrate (Fig. 2.7) [77]. 

Hirschi, K.K. et al.. Endothelial cells modulate the proliferation of mural cell precursors via platelet-derived growth factor-BB and heterotypic cell contact. Circ Res, 1999. 84(3) 298-305. 

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