Atherogenesis endothelial cell function

Tavintharan, S., Lim, S.C., and Sum, C.F., 2009. Effects of niacin on cell adhesion and early atherogenesis biochemical and functional findings in endothelial cells. Basic Clinical Pharmacology Toxicology. 104 206-210. 

Atorvastatin calcium possesses an anti-inflammatory property and reduces the accumulation of inflammatory cells in the atherosclerotic plaques. The drug also inhibits the vascular smooth muscle cell proliferation a key event in the atherogenesis. Atorvastatin also inhibits the platelet function, thereby limiting both the atherosclerosis and the superadded thrombosis and also improves the vascular endothelial function, largely through the amplification of nitric oxide (NO) generation [3-5]. 

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