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Vascular endothelial growth factor tumor blood vessels

In order for a solid tumor to grow beyond a certain size, it must develop a blood supply by elaborating factors such as vascular endothelial growth factor (VEGF). VEGF secreted by the tumor cells diffuses to nearby endothelial cells, which respond by dividing and migrating toward the tumor to eventually develop into blood vessels and vascularize the tumor. [Pg.215]

Dvorak HF, Sioussat TM, Brown LF, Berse B, Nagy JA, Sotrel A, Manseau EJ, Van de Water L, Senger DR. Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors Concentration in tumor blood vessels. J Exp Med 99 -, 174 1275 1278. [Pg.37]

Normalization of tumor vasculature Targeting vascular endothelial growth factor (VEGF) receptors to prune the immature, abnormal blood vessels, so more efficient drug penetration is achieved 147... [Pg.140]

See other pages where Vascular endothelial growth factor tumor blood vessels is mentioned: [Pg.88]    [Pg.156]    [Pg.643]    [Pg.1351]    [Pg.338]    [Pg.469]    [Pg.86]    [Pg.68]    [Pg.120]    [Pg.335]    [Pg.360]    [Pg.366]    [Pg.403]    [Pg.1197]    [Pg.346]    [Pg.579]    [Pg.271]    [Pg.355]    [Pg.399]    [Pg.87]    [Pg.514]    [Pg.195]    [Pg.621]    [Pg.88]    [Pg.156]    [Pg.643]    [Pg.305]    [Pg.671]    [Pg.5]    [Pg.340]    [Pg.29]    [Pg.458]    [Pg.266]    [Pg.938]    [Pg.156]    [Pg.107]    [Pg.450]    [Pg.167]    [Pg.615]    [Pg.510]    [Pg.53]    [Pg.285]    [Pg.346]    [Pg.29]    [Pg.256]    [Pg.252]    [Pg.102]    [Pg.2204]   
See also in sourсe #XX -- [ Pg.371 ]



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345 vascular tumor

Blood vascular

Blood vessels

Endothelial

Endothelial Tumors

Endothelial growth factors

Endothelialization

Tumor growth

Tumor growth factor

Tumor vessel

Vascular endothelial growth

Vascular growth

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