Angiogenesis endothelial growth factor

Liu, L.Z. et al., Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells implication of chemoprevention of lung cancer, Mol. Pharmacol., 68, 635, 2005. 

Bevacizumab is a humanized monoclonal antibody that binds to vascular endothelial growth factor, which prevents it from binding to its receptors, ultimately resulting in angiogenesis. 

Avasti n ) vascular endothelial growth factor (VEGF) and inhibits angiogenesis. Hypertension, bleeding episodes, thrombotic events Additional toxicities Rare perforation of the bowel, proteinurea... 

Compounds that strongly chelate iron have been known for many years to stabilize HIF-la as well as upregulate proteins involved in red blood cell production erythropoietin (EPO), angiogenesis, vascular endothelial growth factor (VEGF), and iron transport. Some, but not all, of the pharmacological actions of iron chelators are produced by inhibition of PHD enzymes resulting in elevation of cellular HIF content. The action of selected iron chelators as they relate to PHD inhibition are briefly summarized here. 

Bagli E, Stefaniotou M, Morbidelli L, Ziche M, Psillas K, Murphy C and Fotsis T. 2004. Luteolin inhibits vascular endothelial growth factor-induced angiogenesis inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3 -kinase activity. Cancer Res 64(21) 7936-7946. 

The antibody brings about its effect by inhibiting angiogenesis (the formation of new blood vessels), a process required to support tumour growth. Specifically, the antibody binds human vascular endothelial growth factor. This prevents the latter from binding to its cell surface receptor, a process central to triggering new blood vessel formation in both normal and diseased tissue. 

Murugesan S, Mousa S, O Connor LJ, Lincoln DW, Linhardt RJ (2007) Carbon inhibits vascular endothelial growth factor- and fibroblast growth factor-promoted angiogenesis. Febs Letters 581 1157-1160. 

Torisel ) antibiotic NP arrest in ttie G1 phase, and inhibits tumor angiogenesis by reducing synthesis of vascular endothelial growth factor (VEGF) ... 

Recent studies have demonstrated that overexpression of HDACl represses the tumor suppressors, p53 and von Hippel-Lindau (VHL), but induces the hypoxia-responsive genes, hypoxia inducible factor alpha (HIF-la) and vascular endothelial growth factor (VEGF) and increases angiogenesis. Conversely, HDAC inhibitors derepress the tumor suppressors, p53 and VHL, and repress HIF-la and VEGF [68, 69]. 

Development of Angiogenesis Inhibitors to Vascular Endothelial Growth Factor Receptor 2 for Cancer Therapy... 

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