Endothelial tumor vasculature

Grunstein J, Masbad JJ, Hickey R, et al, Isoforms of vascular endothelial growth factor act in coordinate fashion to recruit and expand tumor vasculature. Mol Cell Biol 2000 20 7282-7291. 

Backer, M. V., Gaynutdinov, T. I., Patel V., et al. (2005) Vascular endothelial growth factor selectively targets boronated dendrimers to tumor vasculature. Mol. Cancer. Ther. 4, 1423-1429. 

Second, the dynamic nature of protein expression means that it s always cell- and time-dependent. Expression levels in early stage tumor cells will probably vary considerably from those in later stage tumors, and both may have little in common with protein expression levels in, say, endothelial cells that line the tumor vasculature. A tumor cell from an aerobic environment (near blood vessels) will have a different proteomic profile from the one buried deep inside a tumor in an anaerobic environment. These kinds of issues can complicate the interpretation of protein expression in any type of tissue. 

Normalization of tumor vasculature Targeting vascular endothelial growth factor (VEGF) receptors to prune the immature, abnormal blood vessels, so more efficient drug penetration is achieved 147... 

Addressing the impact of irradiation on endothelial cells and the tumor vasculature, they demonstrated that the potentiation of the nitric oxide (NO) signaling pathway after irradiation induces profound alterations in the endotheUal phenotype leading to tumor angiogenesis and that the inhibition of NO production suppresses these provascular effects of irradiation. 

Cyclic peptides that mimic the two regions of the VEGF that are crucial for their interactions with the VEGFR to block the angiogenesis of Ihe tumor vasculature were reported by Goncalves et al Using a competition assay, they showed that heterovalent cyclic peptide constructs inhibited the endothelial cell transduction pathway, migration, and capiUary-like tube formation. 

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