Endothelialization surface-engineered

Surface-engineered endothelialization for artificial cardiovascular implants can be achieved either by allogenic EC seeding or inducing host EC reoccupation. These two strategies may work separately or in coordination. 

The conclusion drawn from the above-discussed features of native endothelium is that—where feasible—construction of host endothelium on the surface of synthetic implants—i.e. engineered endothelialization—may present a promising pathway for fundamentally resolving the biocompatibility and bio-functionality of artificial cardiovascular transplantation. This proposed biocompatibility is, however, not simply thromboresistance (or blood compatibility) plus blood-cell compatibility, but a real bioactive, self-renewable and specifically functional alliance of tissues and synthetics. 

Fernandez P, Bourget C, Bareille R, Daculsi R, Bordenave L. Gene response to endothelial cells cultured on engineered surfaces is regulated by shear stress. Tissue Eng. 13 1607-1614,2007. 

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