Endothelial differentiation gene

An overview of lysophospholipid GPCR is presented in Table 1. Presently best characterized are the receptors of the endothelial differentiation gene (EDG)... [Pg.712]

Rakhit, S., Conway, A-M., Tate, R., Bower, T, Pyne, N.J. and Pyne, S., 1999, Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle role of endothelial differentiation gene-1, c-Src tyrosine kinase and phosphoinositide 3-kinase. Biochem. J. 338 643-649. [Pg.266]

FIGURE 5.5 There are five isoforms of SIP receptors (SlPn 5), a family of G protein-coupled membrane receptors previously known as Edg receptors (endothelial differentiation gene). Ligand binding and activation of SIP receptors initiates multiple intracellular signaling cascades involved in cellular proliferation, differentiation, survival and migration. [Pg.165]

Malek RL, Toman RE, Edsall LC, Wong S, Chiu J, Letterle CA, Van Brooklyn JR, Milstien S, Spiegel S, Lee NH (2001) Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors. J Biol Chem 276 5692-5699... [Pg.44]

Pages C, Daviaud D, An S, Krief S, Lafontan M, Valet P, Saulnier-Blache JS (2001a) Endothelial differentiation gene-2 receptor is involved in lysophosphatidic acid-dependent control of 3T3F442A preadipocyte proliferation and spreading. J Biol Chem 276 11599-11605... [Pg.44]

Goetzl, EJ, Dolezalova, H, Kong, Y, Hu, YL, Jaffe, RB, KalU, KR and Conover, CA (1999) Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer. Cancer Res, 59, 5370-5375. [Pg.101]

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