Dominant-negatives

Vascular gene therapy Transfer of dominant-negative receptors or suicide genes under the control of angiogenic endothelial cell specific promoters... 

The successful clinical application of RTK-based therapeutics in the last 8 years instigates further research to generate the next generation drugs. Thus, antisense RNAs or dominant-negative receptor mutants are being tested for their ability to reduce receptor expression. 

Genome replication Dominant-negative EBNA 1 EBV Nasimuzzaman et al. 2005... 

Nuclear export of unspliced RNA RevMlO Transdominant HIV Rev protein Dominant negative Sam68, a Rev homolog scFv to Rev RRE decoy HIV-1 Habu et al. 2005 Hotchkiss et al. 2004 Li et al. 1998a, b Yamada et al. 1994... 

Nasimuzzaman M, Kuroda M, Dohno S, Yamamoto T, Iwatsuki K, Matsuzaki S, Mohammad R, Kumita W, Mizuguchi H, Hayakawa T, Nakamura H, Taguchi T, Wakiguchi H, Imai S (2005) Eradication of Epstein-Barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNAl. Mol Ther 11 578-590... 

Orsini MJ, Benovic JL (1998) Characterization of dominant negative arrestins that inhibit beta2-adreneigic receptor internalization by distinct mechanisms. J Biol Chem 273(51) 34616-34622 Paredes MF, Li G, Berger O, Baraban SC, Pleasure SJ (2006) Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brains. J Neurosci 26 9404-9412... 

An estrogen receptor P isoform that lacks exon 5 has dominant negative activity on both ErP and Era. Biochem Biophys Res Commun. 279 814-19. 

Nurse So you need a paternal dominant negative cyclin A mutant. 

Barroso I et al. Dominant negative mutations in human PPAR-y associated with severe insulin resistance, diabetes melli-tus and hypertension. Nature 1999 402 880-883. 

Pause, A., Methot, N., Svitkin, Y., Merrick, W. C., and Sonenberg, N. (1994). Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation. EMBO J. 13, 1205-1215. 

Yin, J., Wallach, J., Del Vecchio, M. et al. Induction of a dominant negative CREB transgene specifically blocks long-term memory. Drosophila Cell 79 49-58,1994. 

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