Porcine brain microvessel endothelial cells

PBEC Porcine brain microvessel endothelial cells... 

Preparation of Porcine Brain Microvessel Endothelial Cells... 

Thole, M., et al. 2002. Uptake of cationized albumin coupled liposomes by cultured porcine brain microvessel endothelial cells and intact brain capillaries. J Drug Target 10 337. 

Fig. 3 Relationship between ATP depletion and Pgp expression levels in various cells. The studies included human breast carcinoma cells, MCF-7, and their MDR subline, MCF-7/ADR human oral epidermoid carcinoma cells, KB, and their MDR subline, KBv wUd-type porcine kidney epithelial cells, LLC-PKl, and human MDRl-transfected cells, LLC-MDRl human umbilical vein endothelial cells, HUVEC bovine brain microvessel endothelial cells, BBMEC and murine myoblast cells, C2C12. EC50 values for each of the cell lines were determined from the dose response curves as the concentration of Plutonic P85 inducing a 50% decrease in intracellular ATP following 2 h exposure of the cells to the block copolymer. The drug efflux transport proteins were identified using the im-munoblot technique and normalized to constitutively expressed y3-actin. Plotted using data reported in [33]...

A cell line is a continuously growing cell population, which is derived from tumor cells or from primary cells, which have been immortalized using appropriate vectors. There are several lines of blood-brain barrier endothelial cells available, for example, MBECs (mouse brain endothelial cells), RBE4 cells (rat brain endothelial cells, clone 4), PBMECs (porcine brain microvessel... 

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