Endothelial cell interactions cells

Table 47-14. Some molecules involved in leukocyte-endothelial cell interactions. ...

Lukacs NW, Stricter RM, Elner V, Evanoff HL, Burdick MD, Kunkel SL. Production of chemokines, interleukin-8 and monocyte chemoattractant protein-1, during monocyte endothelial cell interactions. Blood 1995 86(7) 2767-2773. 

Miller ME, Dores GM, Thorpe SL, Akerley WL (1994) Paradoxical influence of estrogenic hormones on platelet-endothelial cell interactions. Thromb Res 74 577-594... 

Zieske JD, Mason VS, Wasson ME, Meunier SF, Nolte CJ, Fukai N, Olsen BR, Par-enteau NL. Basement membrane assembly and differentiation of cultured corneal cells Importance of culture environment and endothelial cell interaction. Exp Cell Res 214 621-633 (1994). 

Although in the early 1990s several antibodies were developed that inhibited leukocyte-endothelial cell interaction to prevent e.g. allograft rejection or inflammatory processes [72], more effort is nowadays put into the development of small molecule antagonists and antisense oligonucleotides for this purpose [73,74], A selection of more recently reported clinical studies with antibodies is summarized in Table 1.2. 

Endothelial cell interaction with ECM and mesenchymal cells is a prerequisite to form a stable vasculature. Therefore, after endothehal cell proliferation and maturation, and the formation of endothehal tube structures, surrounding vessel layers composed of mural cehs... 

Prescribing perspective is to recognize that the previously acceptable counts, on treatment, between (500-650) X (f are hazardous since microvas-cular occlusion, including stroke, remain risks. The concurrent role of aspirin continues to be defined. Thus, while this has a sound theoretical benefit and is recommended to decrease platelet-endothelial cell interaction, occasional gastrointestinal tract bleeding may be found. Furthermore, associated hypercoagulability may be found and determinations of proteins C and S, mutations of factor V and II or elevated homocysteine, as well as the presence of anti-cardiolipin syndrome or lupus anticoagulant should not be overlooked. 

Selectins are a family of plasma membrane lectins that mediate cell-cell recognition and adhesion in a wide range of cellular processes. One such process is the movement of immune cells (T lymphocytes) through the capillary wall, from blood to tissues, at sites of infection or inflammation (Fig. 7-33). At an infection site, P-selectin on the surface of capillary endothelial cells interacts with a specific oligosaccharide of the glycoproteins of circu-... 

Abbott, N.J. 2002. Astrocyte-endothelial cell interactions and blood-brain barrier permeability. J Anat 200 629. 

Barry OP, Pratico D, Savani RC, FitzGerald GA. Modulation of monocyte-endothelial cell interactions by platelet microparticles. J Clin Invest 1998 102 136-144. 

Plaque stabilization Reduced CD40 expression and CD40-related activation of vascular cells Reduced leukocyte-endothelial cell interactions Reduced C-reactive protein levels and proinflammatory cytokines Inhibition of LDL oxidation Reduced cytotoxicity of T-lymphocytes Inhibition of proinflammatoiy T helper 1 cell development and augmentation of anti-inflammatoy T helper 2 cell development Reduced oxidized LDL uptake... 

Pruefer D, Scalia R, Lefer AM. Simvastatin inhibits leukocyte-endothelial cell interactions and protects against inflammatory processes in normocholesterolemic rats, Arterioscler Thromb Vase Biol 1999 19 2894-2900. 

The n-3 PUFAs are reported to reduce expression of endothelial adhesion molecules VCAM-1, E-selectin, and ICAM-1, therefore influencing leukocyte-endothelial cell interactions and leukocyte migration across the endothelium. 105,106 Oxidized EPA has been shown to be a more potent inhibitor of leukocyte-endothelial interaction, in vitro and in vivo, than EPA.107 Since EFAs regulate intercellular adhesion, it has been speculated that the skin changes that are observed in EFA deficiency, may be due, at least in part, to damaged cell adhesion.108 n-3 PUFAs and GLA supplementation enhance E-cadherin expression in cancer cells and this possibly reduces the invasiveness of these cells.109... 

Jodoin J, Demeule M, Fenart L, et al. P-glycoprotein in blood-brain barrier endothelial cells interaction and oligomerization with caveolins. I Neurochem 2003 87(4) 1010-23. 

The majority of more recent structures relate to the sialyl Lewis X blood group carbohydrate receptor function for the selectin family of eukaryote lectins that mediate leucocyte-endothelial cell interaction during the initial stages of extravasation ( neutrophil rolling ) (20). These structures are the sialyl Le , Le, and Le sequences and several 6 sulfo GlcNAc and 3 sulfo Gal derivatives found in both protein and sphingolipid glycoconjugates (21-24). 

Beynon, H.L.C. and Haskard, D.O. (1994). Lymphocyte-endothelial cell interactions. In Immunopharmacology of the Microcirculation (ed. S.D. Brain), pp. 109-126. Academic Press, London. 

N. Gupta, and R. R. Weichselbaum. 2003. Tumour-endothelium interactions in co-cul-ture coordinated changes of gene expression profiles and phenotypic properties of endothelial cells. J Cell Sci 116 1013. 

FSS, whereby a FSS higher than 5 dyns/cm can impede their liver-specific functions [23]. FSS also plays a role in the extravasations of tumour cells as tumour-endothelial cell interactions are dependent on shear [24]. 

Gaboury, J. P., Anderson, D. C., and Kubes, P. (1994). Molecular mechanisms involved in superoxide-induced leukocyte and endothelial cell interactions in vivo. Am. J. Physiol. 266, H637-H642. 

Cassidy, A. S. Bingham K.D. Setchell. Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women. Am. J. Clin. Nutr. 1994, 60, 333-340. Chacko, B.K. R.T. Chandler A. Mundhekar N. Khoo H.M. Pruitt D.F. Kucik D.A. Parks C.G. Kevil S. Barnes R.P. Patel. Revealing anti-inflammatory mechanisms of soy isoflavones by flow Modulation of leukocyte-endothelial cell interactions. Am. J. Physiol Heart Circ. Physiol 2005, 289, 908-915. 

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