Vascular endothelial growth factor inhibition

Spyridopoulos, I., Brogi, E., Kearney, M., Sullivan, A.B., Cetrulo, C., Isner, J.M., and Losardo, D.W. 1997. Vascular endothelial growth factor inhibits endothelial cell apoptosis induced by tumor necrosis factor alpha balance between growth and death signals. J. Mol. Cell. Cardiol. 29 1321-1330. 

DABROSiN c, CHEN J, WANG L and THOMPSON L u (2002) Flaxseed inhibits metastasis and decreases extracellular vascular endothelial growth factor in human breast cancer xenografts. Cancer Lett. 185 (1) 31-7. 

Liu, L.Z. et al., Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells implication of chemoprevention of lung cancer, Mol. Pharmacol., 68, 635, 2005. 

Avasti n ) vascular endothelial growth factor (VEGF) and inhibits angiogenesis. Hypertension, bleeding episodes, thrombotic events Additional toxicities Rare perforation of the bowel, proteinurea... 

Compounds that strongly chelate iron have been known for many years to stabilize HIF-la as well as upregulate proteins involved in red blood cell production erythropoietin (EPO), angiogenesis, vascular endothelial growth factor (VEGF), and iron transport. Some, but not all, of the pharmacological actions of iron chelators are produced by inhibition of PHD enzymes resulting in elevation of cellular HIF content. The action of selected iron chelators as they relate to PHD inhibition are briefly summarized here. 

Bagli E, Stefaniotou M, Morbidelli L, Ziche M, Psillas K, Murphy C and Fotsis T. 2004. Luteolin inhibits vascular endothelial growth factor-induced angiogenesis inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3 -kinase activity. Cancer Res 64(21) 7936-7946. 

The antibody brings about its effect by inhibiting angiogenesis (the formation of new blood vessels), a process required to support tumour growth. Specifically, the antibody binds human vascular endothelial growth factor. This prevents the latter from binding to its cell surface receptor, a process central to triggering new blood vessel formation in both normal and diseased tissue. 

Murugesan S, Mousa S, O Connor LJ, Lincoln DW, Linhardt RJ (2007) Carbon inhibits vascular endothelial growth factor- and fibroblast growth factor-promoted angiogenesis. Febs Letters 581 1157-1160. 

Bevacizumab is a monoclonal antibody that inhibits vascular endothelial growth factor. It should be used with caution in patients with a history of hypertension because of an increased risk of proteinuria and in patients with uncontrolled hypertension. Side-effects that may be expected include... 

Torisel ) antibiotic NP arrest in ttie G1 phase, and inhibits tumor angiogenesis by reducing synthesis of vascular endothelial growth factor (VEGF) ... 

Geng L, Donnelly E, McMahon G, et al. Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy. Cancer Res 2001 61(6) 2413-2419. 

Fong TAT, Shawver LK, Sun L, et al. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-l/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res 1999 59 99-106. 

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