Microvascular endothelial cells

Paris D, Ait-Ghezala G, Mathura VS, Patel N, Quadros A, Laporte V, et al. Anti-angiogenic activity of the mntant Dntch A(beta) peptide on human brain microvascular endothelial cells. Brain Res Mol Brain Res 2005 136 212-30. 

Nakamuta S, Endo H, Higashi Y, Kousaka A, Yamada H, Yano M, Kido H (2008) Human immunodeficiency virus type 1 gpl20-mediated disruption of tight junction proteins by induction of proteasome-mediated degradation of zonula occludens-1 and -2 in human brain microvascular endothelial cells. J Neurovirol 14 186-195... 

HMW High molecular weight HMT Histidine methyltransferase HMVEC Human microvascular endothelial cell... 

Salcedo R, Resau JH, Halverson D, et al. Differential expression and responsiveness of chemokine receptors (CXCR1-3) by human microvascular endothelial cells and umbilical vein endothelial cells. FASEB J 2000 14(13) 2055-2064. 

Heidemann J, Ogawa H, Dwinell MB, et al. Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2. J Biol Chem 2003 278(10) 8508-8515. 

Dzenko KA, Song L, Ge S, et al. CCR2 expression by brain microvascular endothelial cells is critical for macrophage transendothelial migration in response to CCL2. Microvasc Res 2005 90(l-2) 53-64. 

Haraldsen, G., Kvale, D., Lien, B., Farstad, I.N. and Brandtzaeg, P. (1996) Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (IGAM-1), and vascular cell adhesion molecule-1 (VGAM-1) in human microvascular endothelial cells. Journal of Immunology 156, 2558-2565. 

Sickle erythrocytes have increased surface expression of CD36. Microvascular endothelial cells do express CD36. Adhesion between these CD36 molecules of the two cells types can be mediated via the bridging ligand thrombospondin". Indeed plasma thrombospondin levels are increased in SCA patients with pain crisis [15]. 

Jacewicz MS, Acheson DW, Binion DG, West GA, Lincicome LL, Fiocchi C, Keusch GT Responses of human intestinal microvascular endothelial cells to Shiga toxins 1 and 2 and pathogenesis of hemorrhagic colitis. Infect Immun 1999 67 1439-1444. 

BPMVE, bovine pulmonary microvascular endothelial cells... 

P. D. Bowman, A. L. Betz, and G. W. Goldstein. Primary culture of microvascular endothelial cells from bovine retina Selective growth using fibronectin coated substrate and plasma derived serum. In Vitro 18 626-632 (1982). 

Freshly isolated or subcultured brain microvascular endothelial cells offer a notable in vitro tool to study drug transport across the blood-brain barrier. Cells can be grown to monolayers on culture plates or permeable membrane supports. The cells retain the major characteristics of brain endothelial cells in vivo, such as the morphology, specific biochemical markers of the blood-brain barrier, and the intercellular tight junctional network. Examples of these markers are y-glutamyl transpeptidase, alkaline phosphatase, von-Willebrandt factor-related antigen, and ZO-1 tight junctional protein. The methods of... 

Dorovini-Zis K, Pramey R, Bowman PD (1991) Culture and characterization of microvascular endothelial cells derived from human brain. Lab Invest 64 425-436... 

A. R. Gagliardi, M. F. Taylor, and D. C. Colhns. Uptake of suramin by human microvascular endothelial cells. Cancer Lett. 125 97-102 (1998). 

Figure 2.5. Setup for in vitro measurement of blood-brain barrier permeability with a co-culture of bovine brain microvascular endothelial cells (BBMEC) and an astro ioma cell line, C6. The BBMEC are grown on top of a filter insert. The C6 cells are either grown on the opposite side of the filter or on the bottom of the wells. Transport across the BBMEC monolayer is measured by adding the test substance to the upper chamber and sampling from the lower chamber. The tightness of the monolayer is also characterized by the transendothelial electrical resistance (TEER). Courtesy of T. Abbruscato.

HDMEC human dermal microvascular endothelial cell... 

Apart from its potent antiproliferative activity, tetrasaccharide 15 was effective in blocking human complement in vitro and inhibited the release of heparan sulfate from cardiac microvascular endothelial cells. To overcome hyperacute rejection, the tetrasaccharide has been investigated in a guinea pig to rat cardiac xenotransplantation model and significantly prolonged the survival of heart recipients when compared to control and heparin treated groups [46]. 

Pepper MS, Meda P Basic fibroblast growth factor increases junctional communication and connexin 43 expression in microvascular endothelial cells. J Cell Physiol 1992 153 196-205. 

Angeli, V., Faveeuw, C., Delerive, P., Fontaine, J., Barriera, Y., Franchimont, N., Staels, B., Capron, M. and Trottein, F. (2001) Schistosoma mansoni induces the synthesis of IF-6 in pulmonary microvascular endothelial cells role of IF-6 in the control of lung eosinophilia during infection. European Journal of Immunology 31,2751-2761. 

Gupta, K., Kshirsagar, S., Li, W., Gui, L., Ramakrishnan, S., Gupta, P. etal. (1999) VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling. Exp. Cell Res., 247, 495-504. 

Eue I, Sorg C. 2001. Arachidonic acid specifically regulates binding of S100A8/9, a heterodimer complex of the S100 class of calcium binding proteins, to human microvascular endothelial cells. Atherosclerosis 154(2) 505—508. 

R. Hamanaka, K. Kohno, T. Seguchi, K. Okamura, A. Morimoto, M. Ono, J. Ogata and M. Kuwano, Induction of low density lipoprotein receptor and a transcription factor SP-1 by tumor necrosis factor in human microvascular endothelial cells, J. Biol. Chem. 267 (1992) 13160-13165. 

S. M. Sagnella, F. Kligman, E. H. Anderson, J. E. King, G. Murugesan, R. E. Marchant, and K. Kottke-Marchant, Human microvascular endothelial cell growth and migration on biomi-metic surfactant polymers, Biomaterials, 25 (2004) 1249-1259. 

Plendl J, Snyman C, Naidoo S, Sawant S, Mahabeer R, Bhoola KD. Expression of tissue kallikrein and kinin receptors in angiogenic microvascular endothelial cells. Biol Chem 2000 381 1103-1115. 

Jy W, Jimenez JJ, Mauro LM, Ahn YS, Newton KR, Mendez AJ, Arnold PI, Schultz DR. Agonist-induced capping of adhesion proteins and microparticle shedding in cultures of human renal microvascular endothelial cells. Endothelium 2002 9 179-189. 

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