Vascular endothelial tissue peptidases

Vascular endothelial tissue peptidases and soluble plasma peptidases further contribute to peptide hydrolysis. As a consequence, the plasma half-life of most peptides is limited to minutes, as shown for endogenous peptides, such as angiotensin 11 and glucagon-like peptide 1 (Deacon et al., 1995 Werle Bemkop-Schniirch, 2006). In order to exert anti-hypertensive effect the ACE-inhibitory peptides need to resist different peptidases, such as ACE. In this regard ACE-inhibitory peptides can be classified into three groups the inhibitor type, of which the IC50 value is not affected by pre-incubation with ACE the substrate type, peptides that are hydrolysed by ACE to yield peptides with a weaker activity the pro-drug type inhibitor, peptides that are converted to true inhibitors by ACE or other proteases/peptidases. Only peptides... 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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