Platelet endothelial cell adhesion molecule PECAM

Other members of the Ig-superfamily function in conjunction with counter-receptors from separate families of adhesion molecules in various events such as leukocyte trafficking and the movement of immune cells and probably tumor cells across cell barriers in inflammation and metastasis. These glycoproteins (Fig. 10) are the immune cell adhesion molecules ICAM-1, -2 and -3, the vascular cell adhesion molecule VCAM and the platelet-endothelial cell adhesion molecule PECAM [131-134]. 

Cell adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), platelet endothelial cell adhesion molecule (PECAM) and E-selectin have been associated with atherogenesis and progression of disease. These are molecules which are expressed in endothelial cells, platelets and white blood cells. Their increased expression has been associated with the adhesion, recruitment and migration of white blood cells in vascular surfaces, essential processes in atherosclerosis (Vaccari et al. 2007a,b). 

PE Phosphatidylethanolamine PECAM-1 Platelet endothelial cell adhesion molecule-1 also known as CD31... 

Kroll H, Sun QH, Santoso S. Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a target glycoprotein in drug-induced thrombocytopenia. Blood 2000 96(4) 1409-14. 

PECAM (Platelet Endothelial Cell Adhesion Molecule)... 

Duncan GS, Andrew DP, Takimoto H et al. (1999) Genetic evidence for functional redundancy of platelet/endothelial cell adhesion molecule-1 (PECAM-1) CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions. J Immunol 162 3022-3030 Mahooti S, Graesser D, Patil S et al. (2000) PECAM-1 (CD 31) expression modulates bleeding time in vivo. Am J Pathol 157 75-81... 

VE)-cadherin and platelet endothelial cell adhesion molecule-1 (PECAM-1). VE-cadherin is an endothelial-specific Ca " -regulated protein that is linked to the cytoskeleton via catenins (Fig. 1). PECAM-1, also known as CD31, is a key participant in the migration of blood-borne cells across the BBB. Changes in the adherent junction proteins can lead to increased paracellular permeability (Abbruscato and Davis, 1999) and leukocyte trafficking in the CNS (Newman, 1994 Garrido-Urbani et al., 2008). 

Thompson RD, Noble KE, Larbi KY, Dewar A, Duncan GS, Mak TW, Nourshargh S Platelet-endothelial cell adhesion molecule-1 (PECAM-l)-deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration throu the perivascular basement membrane. Blood 2001 97 1854-1860. 

PECAM platelet endothelial cell adhesion molecule... 

Key PMN, polymorphonuclear leukocytes EC, endothelial cell lymphs, lymphocytes CD, cluster of differentiation iCAM, intercellular adhesion molecule LFA-1, lymphocyte function-associated antigen-1 PECAM-1, platelet endothelial cell adhesion cell molecule-1. 

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