Antibodies anti endothelial cell binding

Selectins include P-selectin (platelet selectin), E-selectin (endothelial cell selectin), and L-selectin (leukocyte selectin). P-selectin enables binding of platelets, polymorphonuclear leukocytes, and monocytes to activated endothelial cells and of leukocytes to activated platelets. P-selectin is expressed in the kidneys in systemic lupus erythematosis [266, 267]. The up-regulation of P-selectin expression in glomerui following binding of anti-GBM antibody may be an... 

In early studies it was found that anti-ICAM-1 monoclonal antibodies did not inhibit the LFA-1-dependent adhesion of some cell types suggesting the presence of other LEA-1-binding molecules. The molecules have now been identified, cloned and sequenced and shown to be ICAM homologues. ICAM-2 (Fig. lOb) is found on endothelial cells even in the unstimulated state and may play a key role in the circulation of normal lymphocytes [148]. ICAM-2 is an integral membrane glycoprotein with two Ig-Iike domains that have closest sequence homologies with the two most N-terminal domains of ICAM-1 [149]. There are six Af-glycosylation sites and the size difference... 

Muzykantov et al. (1987) postulated that an antioxidant enzyme conjugated with a specific endothelial ligand will bind to endothelial cells and protect them against oxidative injury. Sakharov et al. (1987) documented that indirect targeting of catalase mediated by polyclonal anti-endothelial antibody protects cultured endothelial cells against the cytotoxic effects of H2O2. Atochina et al. (1998)... 

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