Vascular endothelial growth factor, gene therapy

Shyu, K. G., Chang, H., Wang, B. W., and Kuan, P. 2003. Intramuscular vascular endothelial growth factor gene therapy in patients with chronic critical leg ischemia. American Journal of Medicine, 114, 85-92. 

Wang, Y. Z., Ripa, R. S., Jorgensen, E., Hesse, B., Mortensen, S., and Kastrup, J. 2007. Mobilization of haematopoietic and non-haematopoietic cells by granulocyte-colony stimulating factor and vascular endothelial growth factor gene therapy in patients with stable severe coronary artery disease. Scandinavian Cardiovascular Journal, 41,397-404. 

Kusumanto, Y. H., Van Weel, V., Mulder, N. H., Smit, A. J., Van DEN Dungen, J. J. A. M., Hooymans, J. M. M., Sluiter, W. J., Tio, R. A., Quax, P. H. A., Cans, R. O. B., Dullaart, R. P. R, and Hospers, G. A. P. 2006. Treatment with intramuscular vascular endothelial growth factor gene compared with placebo for patients with diabetes mellitus and critical limb ischemia A double-blind randomized trial. Human Gene Therapy, 17,683-691. 

Kim HJ, Jang SY, Park JI, Byun J, eet al. 2004. Vascular endothelial growth factor-induced angiogenic gene therapy in patients with peripheral artery disease. Exp Mol Med. 36 336-344. 

Tio, R.A., Tkebuchava, T., Scheuermann, T.H., Lebherz, C., Magner, M., Kearny, M. et al. (1999) Intramyocardial gene therapy with naked DNA encoding vascular endothelial growth factor improves collateral flow to ischemic myocardium. Hum. Gene Ther., 10, 2953-2960. 

Senior, K. (2000) Gene therapy A rocky start to the new millennium. Mol. Med. Today, 6, 93. Symes, J.F., Losordo, D.W., Vale, P.R., Lathi, K.G., Esakof, D.D., Mayskiy, M. et al. (1999) Gene therapy with vascular endothelial growth factor for inoperable coronary artery disease. Ann. Thorac. Surg., 68, 830-837. 

Symes Jp Losordo DW, Vale PR, et al. Gene therapy with vascular endothelial growth factor for inoperable coronary artery disease. Ann Thorac Surg I 999 68(3) 830—836. 

Masaki I, Yonemitsu Y Yamashita A, et al. Angiogenic gene therapy for experimental critical limb ischemia acceleration of limb loss by overexpression of vascular endothelial growth factor 165 but not of fibroblast growth factor-2. Circ Res 2002 90(9) 966-973,... 

Kastrup J, Jorgensen E, Ruck A, et al. Direct intramyocardial plasmid vascular endothelial growth factor-AI 65 gene therapy in patients with stable severe angina pectoris A randomized double-blind placebo-controlled study the Euroinject One trial. J Am Coll Cardiol 2005 45(7) 982-988. 

Hiasa, K., Ishibashi, M., Ohtani, K., Inoue, S., Zhao, Q., et al. 2004. Gene transfer of stromal cell-derived factor-1 alpha enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway next-generation chemokine therapy for therapeutic neovascularization. Circulation 109 2454-2461. 

Angiogenesis, or growth of new blood vessels, appears essential in revascularization after myocardial infarction as well as in treating coronary artery disease and peripheral artery disease. Therefore, cardiovascular gene therapy has concentrated on vascular endothelial growth factor (VEGF) in these diseases (Table 6). 

---