Pulmonary endothelial cells

Sala, R., Moriggi, E., Corvasce, G. and Morelli, D. (1993). Protection by N-acetylcysteine a iinst pulmonary endothelial cell damage induced by oxidant injury. Eur. Respir. J. 6, 440-446. 

Studies on the mechanism of thiourea toxicity have shown that thioureas have a high degree of specificity for pulmonary endothelial cells and that thioureas require metabolic activation before toxic effects are manifested. Reduced glutathione levels have been associated with increased toxicity, but there is no evidence to suggest that the appearance of edema coincides with a decrease in glutathione. Furthermore, the induction of tolerance or resistance is not correlated with an increase in glutathione levels in rats. ... 

Hollinger MA. 1982. Biochemical evidence for pulmonary endothelial cell injury after carbon tetrachloride administration in mice. J Pharmacol Exp Therap 222 641-4. 

Pennella, S. Cooray, ]. J. Lanzillo, R. Chalkley, and P. M. Hassoun. Upregu-lation of xanthine oxidase by tobacco smoke condensate in pulmonary endothelial cells. Toxicol Appl Pharmacol 2003 188(1) 59-68. 

Capillary endothelial cells comprise 30-42% of cells in the alveolar region and comprise the walls of the extensive network of blood capillaries in the lung parenchyma. The endothelium forms a continuous, attenuated cell layer that transports respiratory gases, water, and solutes. However, it also forms a barrier to the leakage of excess water and macromolecules into the pulmonary interstitial space. Pulmonary endothelial cells, like type I cells, are vulnerable to injury from inhaled substances and substances in the systemic circulation. Injury to the endothelium results in fluid and protein leakage into the pulmonary interstitium and alveolar spaces, resulting in pulmonary edema. 

Rounds, S., Lu, Q., Harrington, E.O., Newton, J., and Casserly, B. (2008). Pulmonary endothelial cell signaling and function. Trans Am Clin Climatol Assoc 119 155-167,... 

Griffiths, G.D., Lindsay, C.D., Upshall, D.G. (1994). Examination of the toxicity of several protein toxins of plant origin using bovine pulmonary endothelial cells. Toxicology 90 11-27. 

Zhao Y, Natarajan V, Garcia JGN. Pulmonary endothelial cell... 

Anorexigen-associated severe pulmonary hypertension is clinically and histopathologically indistinguishable from idiopathic or primary pulmonary hypertension. Analysis of clonaUty in microdissected endothelial cells of plexi-form lesions in two patients with anorexigen-associated pulmonary hypertension showed a monoclonal expansion of pulmonary endothelial cells. Accelerated growth of pulmonary endothelial cells in response to anorexigens in patients with predisposition to primary pulmonary hypertension has been speculated (75). 

Lesions of pulmonary endothelial cells Gl tract hemorrhage portal vein thrombosis Long-lasting renal vasoconstriction... 

Hyperoxia was toxic to cultured human pulmonary endothelial cells, with impairment of replicative function (expressed as growth impairment index), monitored by cell number determination and triti-ated thymidine incorporation. 

Martin, W. J., Neutrophils kill pulmonary endothelial cells by a hydrogen peroxide-dependent pathway. An in vitro model of neutrophil-mediated injury,Am. Rev. Respir. Dis., 68, 1394, 1981. 

Cultures of bovine pulmonary endothelial cells undergo apoptotic cell death when exposed to... 

Activated neutrophils and platelets adhere to the pulmonary capillary endothelium, initiating multiple inflammatory cascades with a release a variety of toxic substances. There is diffuse pulmonary endothelial cell injury, increased capillary permeability, and alveolar epithelial cell injury. Consequently, interstitial pulmonary edema occurs and gradually progresses to alveolar flooding and collapse. The end result is loss of functional alveolar volume, impaired pulmonary compliance, and profound hypoxemia. ... 

Shaul, P. W., and Wells, L. B. (1994). Oxygen modulates NO production selectively in fetal pulmonary endothelial cells. Am. J. Respir. Cell Mol. Biol. 11, 432-438. 

Pitt BR, Schwarz M, Woo ES, Yee E, Wasserllos K, Tran S, Weng W, Mannix RJ, Watkins SA, Tyurina YY, Tyurin VA, Kagan VE, Lazo JS. Overexpression of melallothionein decreases sensitivity of pulmonary endothelial cells to oxidant injury. Am J Physiol 1997 273 L856-L865. 

Zhao Y, Davis HW Hydrogen peroxide-induced cytoskeletal rearrangement in cultured pulmonary endothelial cells. J Cell Physiol 1998 174 370-379. 

Suttorp N, Nolte A, Wilke A, Drenckhahn D Human neutrophil elastase increases permeability of cultured pulmonary endothelial cell monolayers. Int J Microcirc Clin Exp 1993 13 187-203. 

Meyrick, B.O. (1986). Endotoxin-mediated pulmonary endothelial cell injury. Fed. Proc., 45, 19-24... 

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