Rolling leukocytes

Kubes P. Kanwar S Histamine induces leukocyte rolling in post-capillary venules. A P-selectin-mediated event. J Immunol 1994 152 3570-3577. 

Yamaki K, Thorlacius H. Xie X. Lindbom L, Hedqvist P. Raud J Characteristics of histamine-induced leukocyte rolling in the undisturbed microcirculation of the rat mesentery. Br J Pharmacol 1998 123 390-399. 

Mayadas, T.N., R.C. Johnson, H. Rayburn, R.O. Hynes, and D.D. Wagner. 1993. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell. 74 541-54. 

Sperandio M. Selectins and glycosyltransferases in leukocyte rolling in vivo. FEES J. 2006 273 4377-4389. 

CD62L L selectin, LECAM-1. Mediates lymphocyte homing to high endothelial venules of peripheral lymphoid tissue, leukocyte rolling on activated endothelium at inflammatory sites. 

Lawrence, M. B. and Springer, T. A. (1991). Leukocytes roll on a selectin at physiologic flow rates distinction from and prerequisite for adhesion through integrins. Cell 65, 859-873. 

Mayrovitz, H. N. (1992). Leukocyte rolling a prominent feature of venules in intact skin of anesthetized hairless mice. Am. J. Physiol. 262, H157-161. 

Several groups have employed polyamino acid backbones as templates for the display of multiple carbohydrate residues [164,165]. For example, potent E-selectin antagonists have been generated from poly lysine [166,167] These materials are highly effective inhibitors of leukocyte rolling. Multivalent polylysine displays have also been used to inhibit Shiga-like toxin binding [168]. 

Chemokine sequestered on the endothelial cell surface represents the signal to transient arrest the leukocyte rolling along the endothelium (selectin and integrin mediated sampling). 

Ley, K., Gaehtgens, P., Finnie, C., Singer, M. S., Lasky, L. A., and Rosen, S. D., Lectin-like adhesion molecule-1 mediates leukocyte rolling in mesenteric venules... 

Intestinal inflammation In an animal model of Crohn s disease (hapten-induced cohtis), ZK-192 administered after disease onset displayed anti-inflammatory bioactions reducing TNF-, interferon-y and interleukin-8 LX modulates neutrophil transmigration across the intestinal epithelial monolayer, inhibits leukocyte rolling and adherence, modulates interleukin-8 release chemokine secretion LX inhibits TNl -o-induced nculrophil-cnlcrocyle interaction, chemokine release and colonocyte apoptosis Fiorucci et al. 2004... 

Scalia R, Gefen J, Petasis NA, Serhan CN, Lefer AM (1997) Lipoxin A4 stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature role of P-selectin. Proc Natl Acad Sci USA 94 9967-9972... 

Many biological processes take place under dynamic rather than static conditions. For example, the ability of the selectins to mediate the dynamic process of leukocyte rolling is a critical aspect of their function yet most selectin inhibitors have been evaluated in static assays. A smdy evaluating multivalent L-selectin inhibitors revealed dramatic differences in their activities in static cell free versus dynamic cell rolling assays. 

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