Endothelial angiogenic vasculature

Other niches comprising reticular and endothelial cells known to secrete factors that promote self-renewal and survival have been found in close association with the vasculature [108]. Since the niche is dependent on the presence of an efficient blood supply, one therapeutic strategy would be to target the niche endothelium. Clinical use of anti-angiogenic agents has accelerated in... 

Fig. 1 Bone marrow and peripheral blood stem cells. (A) Example of a bone marrow-derived MSC and its potential to differentiate into various lineages. Although not depicted in this figure, MSCs also have the potential to differentiate into vascular endothelial cells and promote angiogenesis for vascular repair [19,20]. (B) Differentiation pathway of CD34 peripheral blood stem cells from a hematopoietic stem cell lineage, which can serve to become endothelial cells within the vasculature and possess greater pro-angiogenic effects. Both figures reprinted from [21] and [22], respectively, with permission.

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