Endothelial plaque stability

Plaque stabilization Reduced CD40 expression and CD40-related activation of vascular cells Reduced leukocyte-endothelial cell interactions Reduced C-reactive protein levels and proinflammatory cytokines Inhibition of LDL oxidation Reduced cytotoxicity of T-lymphocytes Inhibition of proinflammatoiy T helper 1 cell development and augmentation of anti-inflammatoy T helper 2 cell development Reduced oxidized LDL uptake... 

Statins are Lovastatin (1), Mevastatin -naturally-occurring compound found in red yeast rice, and Pravstatin. Statins exhibit action beyond lipid-lowering activity in the prevention of atherosclerosis i) Improving endothelial function ii) Modulate inflammatory responses, iii) Maintain plaque stability, and iv) Prevent thrombus formation. 

Auld GC, Ritchie H, Robbie LA, Booth NA. Thrombin upregulates tissue transglutaminase in endothelial cells a potential role for tissue transglutaminase in stability of atherosclerotic plaque. Arterioscler Thromb Vase Biol 2001 21 1689-1694. 

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