Endothelial cells migration and proliferation

Shizukuda, Y., Tang, S., Yokota, R., and Ware, J. A. 1999. Vascular endothelial growth factor-induced endothelial cell migration and proliferation depend on a nitric oxide-mediated decrease in protein kinase C delta activity. Circ. Res. 85 247-256. 

Lee, Y. 1994. Computer-Assisted Analysis of Endothelial Cell Migration and Proliferation. Ph.D. Dissertation. Rice University. 

Geraldes R Sirois MG, Bernatchez PN, Tanguay JE Estrogen regulation of endothelial and smooth muscle cell migration and proliferation role of p38 and p42/44 mitogen-activated protein kinase. Arterioscler Thromb Vase Biol 2002 22 1585-1590. 

Cell migration and proliferation Fibrous scaffolds consisted of nanotubes and polyurethanes were fabricated by electrospinning. The scaffolds promoted endothelial cell proliferation and migration along the aligned fibers. Han et al. Morphology/composition... 

The cerebral endothelial cells of the blood-brain barrier originate from the middle germinal sheet of the embryo, the mesoderm [17]. Concomitant with migration and proliferation of capillary endothelial cells during formation of the cerebral vascular network occurs the imprinting of the cells. Thereby, induction by the cellular surrounding plays an important role [18-21], The relevance of the cellular environment for the development of the barrier function of cerebral microvessels was first demonstrated by Stewart and Wiley [22], who transplanted embryonic brain tissue of a quail into embryonic gut tissue of chicken and vice versa. The cerebral transplant was vascularized by intestinal vessels, in which properties of the blood-brain barrier had been induced. In transplanted brain vessels, however, no characteristics of a barrier could be demonstrated, due to the lack of a neuronal environment. These results indicated that the cerebral microvessels are of extraneuronal origin, with properties that are induced by the cellular environment. In addition, brain tissue has the capability to induce blood-brain barrier characteristics also in noncerebral vascular tissue [23],... 

Ausprunk, D. H., and Folkman, J. 1977. Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc. Res. 14 53-65. 

Endothelial cell migration is mediated by two additional pathways that stimulate cytoskeletal reorganization. These involve the p38 MAPK and focal adhesion kinase with paxillin phosphorylation, respectively [31]. PIP3 also activates the small GTP-binding protein Rac which facilitates endothelial cell migration. The PI3K pathway may also contribute to VEGF-enhanced endothelial cell proliferation [32],... 

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