Reticulo-endothelial system organs

The appearance of clofazimine in the plasma following absorption is short lived (Banerjee et al., 1974), it rapidly passed out of the circulation and is deposited in various tissues and organs, particularly the fatty tissue, the spleen, lymph nodes, and the cells of the reticulo - endothelial system. Concentrations of 2.1-... 

While the typical cells in Gaucher s disease are usually limited to a few organs, NPC may be found almost everywhere in the body. However, corresponding to the distribution of the reticulo-endothelial system they will be most abundant in tissues of this system which therefore should preferably be biopsied for diagnostic purposes. As a rule, NPC cannot be recovered from circulating blood, and, according to Bloom (1928), the vascular endothelium is not a precursor for these cells. 

In an extended study of experimental tissue reactions following intravenous injections of silica and other dusts Simson and Strachan (1940) stated that the distribution of the microscopically visible dust in the organs and tissues of the rabbit in the early stage is the same irrespective of whether the dust later exhibits toxic or non-toxic properties. The chief situations in which it can be found are the organs provided with sinusoids and an active reticulo-endothelial tissue in relation to the blood vascular system, e.g. liver, spleen, bone-marrow and lymph-nodes. 

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