Endocytosis sinusoidal endothelial cells

I. Kosugi, H. Muro, H. Shirasawa, and I. Ito, Endocytosis of soluble IgG immune complex and its transport to lysosomes in hepatic sinusoidal endothelial cells, J. Hepatol. 76 106-114 (1992). 

Magnusson, S., Berg, T., 1993. Endocytosis of ridn by rat liver cells in vivo and in vitro is mainly mediated by mannose receptors on sinusoidal endothelial cells. Biochem. J. 291,749-755. 

B. Smedsrod, J. Melkko, N. Araki, H. Sano, and S. Horiuchi. Advanced glycation end products are eliminated by scavenger-receptor-mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cells, Biochem. J. 322 567-573 (1997). 

S. Magnusson and T. Berg, Extremely rapid endocytosis mediated by the mannose receptor of sinusoidal endothelial rat liver cells, Biochem. J. 257 651-656 (1989). 

To reach the perivascular interstitium, immunoglobulins and other molecules must breach the endothelial cell barrier. Simionescu and Anthohe [17] note that an adult human contains more than 1013 endothelial cells which cover 7000 square meters and mass approximately 1kg.3 Egress to interstitium is affected by type of endothelium (continuous, fenestrated, or sinusoidal), endothelial uptake and transport processes (receptor-dependent or receptor-independent uptake, endocytosis and transcytosis4), paracellular (between or... 

This cooperation not only takes place between the sinusoidal cells, but also with the hepatocytes .) endothelial and Kupffer cells complement each other through various mechanisms of endocytosis and different pathways of enzymatic clearance (2.) as a double barrier, they protect the liver cells both from toxic and undesired substances, even to the extent of self-sacrifice (i.) they intervene in the metabolism of liver cells with self-produced substances 4.) they send signal substances like cytokines (e.g. interferons) and eicosanoids (e.g. leukotrienes) to the liver cells for independent control of biochemical and biomolecular reaction cascades. 

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