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Endothelial cell interactions From lung

Because the cell surface is negatively charged, positively charged compounds interact more intensely with cells than do negatively charged ones. Cationic complexes of plasmid DNA with any cationic vector exhibit very different pharmacokinetic profiles from that of naked plasmid DNA. They avidly bind to endothelial cells and normally accumulate in the lung after intravenous injection due to the first-pass effect.22,23... [Pg.309]

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See also in sourсe #XX -- [ Pg.39 , Pg.40 ]



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