Endothelial cell interactions monolayers

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Kramer, R. H. and Nicolson, G. L. (1979). Interactions of tumor cells with vascular endothelial cell monolayers a model for metastatic invasion. Proc. Natl. Acad. Sci. USA 76, 5704-5708. 

Toezeren, A., Kleinman, H. K., Grant, D. S., Morales, D., Mercurio, A. M. and Byers, S. W. (1995). E-selectin-mediated dynamic interactions of breast and colon cancer cells with endothelial cell monolayers. Int. J. Ctincer 60, 426-431. 

Modulation of the intercellular junctions by inhibiting the cadherin-cadherin interaction at the adherens junction has also been investigated. Peptides derived from the sequence of the extracellular domain of E-cadherin have been shown to modulate the intercellular junction of bovine brain microvessel endothelial cell (BBMEC) and Madin-Darby canine kidney (MDCK) cell monolayers. These peptides enhance the paracellular penetration of marker molecules such as 14C-mannitol and lower the transepithelial resistance of the monolayers.52 55 The use of these cadherin-derived peptides as adjuvants to enhance paracellular permeability of drugs is still under investigation. 

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