Thrombosis endothelial cell products

It will be later proposed that an ideal blood-contacting surface would be one on which endothelial cells could adhere and grow normally to create a complete endothelium endowed with the physiological functions of such tissue. But the correct expression of such physiological functions requires normal blood flow conditions. And the correlation of thrombosis with regions of disturbed flow suggests that shear stress may alter the production of endothelial cell-derived products and directly affect endothelial cell function. 

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