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21-amino-acid peptides

Benzylthio or 2-benzyloxy derivatives of A-2-thiazoline-5-one (224) are readily opened by amines to give the amide derivatives (225) (Scheme 115) (459. 471). Compound 225 can be cyclized thermally to the corresponding thiohydantoins (459). Similarly, treatment of 4-substituted-2-phenylthiazol-5(4H)-ones (226) with amino acids, peptides, or hydrazine affords the corresponding Nfcti-thiobenzamidoacetylated derivatives (227) (Scheme 116) (455). [Pg.433]

Biosynthesis. Somatostatin exists in longer forms in several biological tissues (95,96). One of the longer forms, which has been isolated from porcine intestine, has been characterized as a 28-amino acid peptide (97). Somatostatin is derived from a precursor containing 116 amino acids (98,99). The precursor contains one copy of the somatostatin tetradecapeptide, which is contained within the sequence of the 28-amino acid peptide at the carboxy-terminal end of the precursor. The 28-amino acid somatostatin is preceded by a single Arg residue, while somatostatin 1-14 is preceded by a pair of basic residues. [Pg.203]

CCK has been detected in two principal forms, ie, the traditional 33-amino acid peptide, and an octapeptide CCK-8. The intestine produces mainly CCK-33 (133) and the brain produces mainly CCK-8 (132). The CCK precursor contains one copy of CCK-33 (133,134) this peptide is flanked on both ends with double basic residues, whereas CCK-8 is formed from CCK-33 by cleavage of a single basic residue. [Pg.204]

Atrial Natriuretic Peptide, a-Atrial natriuretic peptide [85637-73-6] (ANP) (55), also known as atrial natriuretic factor (ANF), brain natriuretic peptide (BNP) (56), and type C natriuretic peptide (CNP) (57) are members of the ANP family (28). These atrial peptides arise from a common 128 amino acid precursor where the active form of ANP is the 28 amino acid peptide at the C terminus. [Pg.528]

Calcitonin Gene-Related Peptide. Calcitonia gene-related peptide (CGRP) [83652-28-2] (74) is a 37-amino acid peptide (Fig. 4) (32). [Pg.531]

Amylin [106602-62-4] (75) (Fig. 4) is a 37-amino acid peptide having approximately 46% sequence similarity to CGRP (33). Amylin is present ia pancreatic P-ceUs along with insulin. It may function as a hormone ia glucoregulation and has been proposed as an etiologic factor ia certain forms of diabetes. Amylin is also present ia dorsal root ganglia (see INSULIN AND OTHER ANTIDIABETIC DRUGS). [Pg.531]

Endothelin. The endothelin (ET) peptide family (50) comprises thiee peptides ET-1 (133), ET-2 (134), and ET-3 (135). ET-1, the most abundant, is a 21-amino acid peptide. A 203-amino acid peptide piecuisoi, piepioET, is cleaved after translation by endopeptidases to form a 38-amino acid proET which is converted to active ET by a putative endothelin-converting enzyme (ECE). ET-3 differs from ET-1 and ET-2 by sis amino acids. [Pg.542]

Insulin and Amylin. Insulin is a member of a family of related peptides, the insulin-like growth factors (IGFs), including IGF-I and IGF-II (60) and amylin (75), a 37-amino acid peptide that mimics the secretory pattern of insulin. Amylin is deficient ia type 1 diabetes meUitus but is elevated ia hyperinsulinemic states such as insulin resistance, mild glucose iatolerance, and hypertension (33). Insulin is synthesized ia pancreatic P cells from proinsulin, giving rise to the two peptide chains, 4. and B, of the insulin molecule. IGF-I and IGF-II have stmctures that are homologous to that of proinsulin (see INSULIN AND OTHER ANTIDIABETIC DRUGS). [Pg.555]

J (339), a 28-amino acid peptide, is a member of a family of stmctuially related peptides that includes secretin [1393-25-5] (340), growth hormone releasing factor (GRF), and pituitary adenylate cyclase-activating peptide (PACAP) [137061(341) (83). [Pg.578]

At the time of the discovery of Met-enkephalin, its sequence was observed to be identical to that of residues 61—65 contained in the C-fragment of the pituitary hormone p-Hpotropin [12584-99-5] (p-LPH) (see Hormones), first isolated in 1964 (11). In 1976, the isolation of a larger peptide fragment, P-endorphin [60617-12-1] that also displayed opiate-like activity was reported (12). This peptide s 31-amino-acid sequence comprised residues 61—91 of P-LPH. Subsequentiy, another potent opioid peptide, dynorphin [72957-38-17, was isolated from pituitary (13). The first five amino acids (qv) of this 17-amino-acid peptide are identical to the Leu-enkephalin sequence (see Table 1). [Pg.444]

I inhydrin-Color Reaetion, This reaction is commonly used for qualitative analysis of a-amino acids, peptides, and proteins. [Pg.281]

Specialist Periodical Reports Amino-Acids, Peptides, and Proteins, Royal Society of Chemistry, London,. Vols. 1-16 (1969-1983) Amino Acids and Peptides, Vols. 17-21 (1984-1990). [Pg.227]

Melanotropin. [9034-42-8] (18-22 amino acids peptide), amorphous. Extract separated by ion-exchange on carboxymethyl cellulose, desalted, evapd and lyophilised, then chromatographed on Sephadex G-25. [Lande et al. Biochem Prep 13 45 1971.]... [Pg.546]

Amines, Amino acids, peptides, e g tryptophan, tryptamine, peptides with terminal tryptophan groups... [Pg.76]

Carey Organic Chemistry, I 27. Amino Acids, Peptides, I Text Fifth Edition and Proteins... [Pg.1109]


See other pages where 21-amino-acid peptides is mentioned: [Pg.37]    [Pg.167]    [Pg.1109]    [Pg.330]    [Pg.200]    [Pg.203]    [Pg.204]    [Pg.381]    [Pg.251]    [Pg.219]    [Pg.458]    [Pg.208]    [Pg.25]    [Pg.504]    [Pg.546]    [Pg.167]    [Pg.1109]    [Pg.1110]    [Pg.1113]    [Pg.1115]    [Pg.1116]    [Pg.1117]    [Pg.1118]    [Pg.1119]   
See also in sourсe #XX -- [ Pg.45 , Pg.87 , Pg.168 , Pg.179 , Pg.257 , Pg.275 , Pg.363 , Pg.374 , Pg.417 , Pg.428 , Pg.430 ]




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0-Amino acid peptides, prepn

21-amino-acid peptides 2 + 2 + 2]-cycloaddition reactions

A- Amino Acids, Peptides, and Proteins

Abbreviated Designations of Substituted Amino Acids and Peptides

Aliphatic Amines, Amino Acids, Peptides and Proteins

Amino Acid Residues and Peptide Bonds

Amino Acid and Peptide Analytes

Amino Acid and Peptide Guanidines

Amino Acid and Peptide Metabolism

Amino Acid, Peptide, and Protein Analytes

Amino Acids and the Peptide Bond

Amino Acids, Peptides, Proteins, and Enzymes

Amino Acids, Related Compounds, and Peptides

Amino acid analysis of peptides

Amino acid diastereoisomeric peptides

Amino acid esters peptide synthesis

Amino acid peptide bonds

Amino acid peptide bonds joining

Amino acid peptide synthesis from

Amino acid sequence determination, peptides

Amino acid sequences Peptides

Amino acid sequences in peptides

Amino acid-derived peptides

Amino acid/peptide bioconjugates

Amino acids Peptides Proteins

Amino acids Protein/peptide analysis

Amino acids and peptides

Amino acids and simple peptides

Amino acids backbone peptide groups

Amino acids degradation during peptide hydrolysis

Amino acids from peptides

Amino acids in peptides

Amino acids in peptides and proteins

Amino acids peptide arrays

Amino acids peptide bonding between

Amino acids peptide chain length

Amino acids peptide synthesis

Amino acids peptides and polypeptides

Amino acids residues of a peptide

Amino acids self-assembling cyclic peptides

Amino acids soil peptides

Amino acids solid phase peptide synthesis

Amino acids, analysis peptide linkage

Amino acids, conformationally cyclic peptides

Amino acids, conformationally membrane-binding peptides

Amino acids, conformationally peptide hormones

Amino acids, equilibrium with peptides

Amino acids, peptides and proteins some terminology

Amino acids, peptides, and proteins

Amino-acid sequencing of peptides

Aminolysis of Succinimido Esters by Unprotected Amino Acids or Peptides

Binding of Amino Acids and Peptides

Biochemistry peptide bonding between amino acids

Biomolecules Amino Acids, Peptides, and Proteins

Cadmium(II) Complexes of Amino Acids and Peptides

Catalysis, amino acids/peptides

Complexes of Amino Acids and Peptides

Detection of amino acids and peptides separated by GLC

Fragmentation reactions amino acids/peptides

Free Amino Acids, Peptides

Interaction of Platinum Agents with Amino Acids, Peptides and Proteins

Introduction amino acid-derived peptide

Introduction the main conformational features of amino acids and peptides

Introduction to Amino Acids, Peptides and Proteins

Introduction. Amino Acids and a Few Early Paradigmatic Peptides

Metal-binding properties of amino acids and peptides

Modifications of Amino Acids and Peptides via Radicals

N-terminal amino acids, of peptides

Nitrones peptides and amino acids

Novel Amino Acid-Derived Template Molecules For Protein Epitope Mapping Using Conformationally Constrained Small Peptides

Oxidation of Amino Acids in Proteins and Peptides

Peptide amino acid residues

Peptide amino acid sequencing

Peptide bond between amino acids

Peptide fragments amino acid sequences

Peptide surfactants amino acid

Peptide trifunctional amino acid protection

Peptide, amino acid sequence analysis

Peptide, amino acid sequence cross-linked

Peptide, amino acid sequence cysteine-containing

Peptide, amino acid sequence highly-charged precursor

Peptide, amino acid sequence histidine-containing

Peptide, amino acid sequence intramolecular backbone bonds

Peptide, amino acid sequence methionine-containing

Peptide, amino acid sequence phosphorylated

Peptides acids

Peptides amino acid analysis

Peptides amino acid chelates

Peptides amino acid composition

Peptides amino acid ester chelates

Peptides amino acid metal complexes

Peptides amino acid terminal residue

Peptides amino acid uptake

Peptides biosynthesis, from amino acid esters

Peptides uncommon amino acids

Peptides, amino acid mimics

Peptides, antibiotic amino acids

Peptides, detection amino acids

Polypeptide A polymer composed of amino acids linked by peptide bonds

Reactions of amino acids and peptides

Role of free amino acids and peptides

SOLID-PHASE SYNTHESIS OF HETEROCYCLES FROM PEPTIDES AND AMINO ACIDS

Separation of amino-acid and peptide mixtures

Separation of proteins, peptides, and amino acids

Solid-phase peptide synthesis amino acid side chain protecting groups

Solid-phase peptide synthesis coupling protected amino acids

Solid-phase peptide synthesis polymer-bound amino acid

Solid-phase synthesis of unnatural amino acids and peptides

Terminal Amino Acids in Peptides and

Tetrasubstituted Amino Acids-Containing Peptides

The Building Blocks of Proteins Amino Acids, Peptides, and Polypeptides

Thiazolium Amino Acid Chimera Peptides

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