Liver endothelialitis

M. K. Bijsterbosch, W. Donker, H. Van de Bilt, S. Van Weely, T. J. Van Berkel, and J. M. Aerts, Quantitative analysis of the targeting of mannose-terminal glucocerebrosidase. Predominant uptake by liver endothelial cells, Eur. J. Biochem., 237 (1996) 344-349. 

The most abundant cell type in the liver is the hepatocyte, other cells in the liver are the non-parenchymal cells Kupffer cells, the resident macrophages of the liver, endothelial cells and stellate cells. These cells have been discussed in more detail in Chapter 4. 

Figure 1 Schematic representation of the architecture of the liver. Endothelial cells (EC) and Kupffer cells (KC) are located in close contact with the bloodstream, whereas hepatic stellate cells (HSC) and parenchymal cells (PC) reside in or behind the space of Disse.

M. van Oosten, E. van de Bilt, T. J. C. Van Berkel, and J. Kuiper. New scavenger receptor-like receptors for the binding of lipopolysaccharide to liver endothelial and Kupffer cells, Infect. Immun. 66 5107-5112 (1998). 

N. Forsberg and S. Gustafson, Characterization and purification of the hyaluronan-receptor on liver endothelial cells, Biochim. Biophys. Acta 7078 12-18 (1991). 

J. Melkko, T. Hellevik, L. Risteli, J. Risteli, and B. Smedsrod, Clearance of NH2-terminal propeptides of types I and III procollagen is a physiological function of the scavenger receptor in liver endothelial cells, J. Exp. Med. 779 405-412 (1994). 

T. Hellevik, I. Martinez, R. Olsen, B. H. Toh, P. Webster, and B. Smedsrod, Transport of residual endocytosed products into terminal lysosomes occurs slowly in rat liver endothelial cells, Hepatology 28 1378-1389 (1998). 

M. R. Daha. 1991. Kupffer cell depletion in vivo results in preferential elimination of IgG aggregates and immune complexes via specific Fc receptors on rat liver endothelial cells. Clin. Exp. Immunol. 86 328-333. 

Parenchymal liver cells Kupffer cells Liver endothelial cells Leucocytes Galactose, polymeric IgA, cholesterol ester-VLDL, LDL Mannose-fucose, galactose (particles), (oxidized) LDL Mannose, acetylated LDL Chemotactic peptide, complement C3b... 

Smedsrod B, Malmgren M, Ericsson J, Laurent TC. Morphological studies on endocytosis of chondroitin sulphate proteoglycan by rat liver endothelial cells. Cell Tiss Res 1988 253 39-45. 

Human thoracic lymph 0.2-50 The low molecular mass of this HA is explained by the preferential uptake of the larger molecules by the liver endothelial cells. 

Seo YS, Kwon JH, Yaqoob U, Yang L, de Assuncao TM, Simonetto DA, Verma VK, Shah VH (2013) HMGB1 recruits hepatic stellate cells and liver endothelial cells to sites of ethanol induced parenchymal cell injury. Am J Physiol Gastrointest Liver Physiol. doi 10.1152/ajpgi.00151.2013... 

KMO is a NADPH-dependant flavin monooxygenase which is localized to the outer membrane of mitochondria [66]. KMO is expressed at high levels in the liver, endothelial cells, and monocytic cells and to a lower extent in the brain. Here, its expression is mainly found in cells of glial nature, specifically in microglial cells and in infiltrating macrophages, whereas little or no expression has been found in astrocytes or in neurons [12, 67]. However, the lack of good antibodies to detect... 

Magnusson S, Kjeken R and Berg T (1993). Characterization of two distinct pathways of endocytosis of ricin by rat liver endothelial cells. Exp Cell Res, 205, 118-125. 

Matsumura T, Takesue M, Westerman K A, et al. (2004). Establishment of an immortalized human-liver endothelial cell line with SV40T and hTERT. Transplant. 77 1357-1365. 

Snawder JE, Roe AL, Benson RW, Roberts DW (1994) Loss of CYP2E1 and CYP1A2 activity as a function of acetaminophen dose relation to toxicity. Biochem Biophys Res Cmiunun 203 532-539 Steinberg P, Schlemper B, Molitor E, Platt KL, Seidel A, Oesch F (1990) Rat liver endothelial and Kupffer cell-mediated mutagenicity of polycyclic aromatic hydrocarbons and afiatoxin Bl. Environ Health Perspect 88 71-76... 

Tomasi, V., Meringolo, C., Bartolini, G. and Orlandi, M. (1978). Biosynthesis of prostacyclin in rat liver endothelial cells and its control by prostaglandin E2. Nature (London), 273, 670-671... 

Boudeau J, Miranda-Saavedra D, Barton GJ et al (2006) Emerging roles of pseudokinases. Trends Cell Biol 16 443-452 Brakebusch C, Fassler R (2003) The integrin-actin connection, an eternal love affair. EMBO J 22 2324-2333 Braun A, Bordoy R, Stanchi F et al (2003) PINCH2 is a new five LIM domain protein, homologous to PINCH and localized to focal adhesions. Exp Cell Res 284 239-250 Brodt P, Fallavollita L, Bresalier RS et al (1997) Liver endothelial E-selectin mediates carcinoma cell adhesion and promotes liver metastasis. Int J Cancer 71 612-619 Brooks PC, Stromblad S, Sanders LC et al (1996) Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3. Cell 85 683-693... 

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