Liquid chromatography mass

Liquid chromatography/mass spectrometry (LC/MS) is an analytical technique combining the advantages of an LC instrument with those of a mass spectrometer. 

Brown, M.A., Liquid Chromatography/Mass Spectrometry Applications in Agricultural, Pharmaceutical and Environmental Chemistry, Oxford University Press, Oxford, 1998. 

Niessen, W.M.A. and van der Greef, J, Liquid Chromatography-Mass Spectrometry, Marcel Dekker, New York, 1992. 

Yergey, A.L., Edmonds, C.G., Lewis, I.A.S., and Vestal, M.L., Liquid Chromatography/Mass Spectrometry Techniques and Applications, Plenum Press, New York, 1990. 

During gc/ms or liquid chromatography/mass spectrometry (Ic/ms) acquisitions, it is possible to perform a mixture of the experiments described in Table 2 for different time windows, with the experimental parameters, such as the coUision energy, optimized for each analyte. 

A liquid chromatography-mass spectrometry (LC-MS) method that can quantitatively analyze urinar y normal and modified nucleosides in less than 30 min with a good resolution and sufficient sensitivity has been developed. Nineteen kinds of normal and modified nucleosides were determined in urine samples from 10 healthy persons and 18 breast cancer patients. Compounds were separ ated on a reverse phase Kromasil C18 column (2.1 mm I.D.) by isocratic elution mode using 20 mg/1 ammonium acetate - acetonitrile (97 3 % v/v) at 200 p.l/min. A higher sensitivity was obtained in positive atmospheric pressure chemical ionization mode APCI(-i-). 

Very little in the way of advances has occurred since 1971 in the applications of ultraviolet or infrared spectroscopy to the analysis of fluonnated organic compounds Therefore, only gas-liquid chromatography, liquid chromatography, mass spectrometry, and electron scattering for chemical analysis (ESCA) are discussed The application of nuclear magnetic resonance (NMR) spectroscopy to the analysis of fluonnated organic compounds is the subject of another section of this chapter... 

G. S. Rule, A. V. Moi dehai and J. Henion, Determination of carbofuran by on-line immunoaffinity cliromatography with coupled-column liquid chromatography/mass spectrometiy . Aim/. Chem. 66 230-235 (1994). 

The ion spray liquid chromatography/mass spectrometry (LC-MS) interface coupled via a postsuppressor split with an ion chromatography (IC) has been used in the analysis of alcohol sulfates. The IC-MS readily produces the molecular weight while the tandem mass spectrometric detection IC-MS-MS provides structural information [305]. 

Hummel D, Loffler D, Fink G, Temes TA (2006) Simultaneous determination of psychoactive drugs and their metabolites in aqueous matrices by liquid chromatography mass spectrometry. Environ Sci Technol 40 7321-7328... 

Farre M, Ferrer I, Ginebreda A, Figueras M, Olivella L, Tirapu L, Vilanova M, Barcelo D (2001) Determination of drugs in surface water and wastewater samples by liquid chromatography-mass spectrometry methods and preliminary results including toxicity studies with Vibrio fischeri. J Chromatogr A 938 187-197... 

Liquid Chromatography -Mass Spectrometry An Introduction. Robert E. Ardrey... 

In this book, I have tried to show the way in which high performance liquid chromatography-mass spectrometry (LC-MS) has developed, somewhat slowly it has to be said, into a powerful hybrid analytical technique. 

The characteristics of an ideal liquid chromatography-mass spectrometry interface have been discussed, with emphasis having been placed upon the major incompatibilities of the two component techniques that need to be overcome to allow the combination to function effectively. 

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