Liquid chromatography-mass books

In this book, I have tried to show the way in which high performance liquid chromatography-mass spectrometry (LC-MS) has developed, somewhat slowly it has to be said, into a powerful hybrid analytical technique. 

Fernandez, M.L., and Reguera, B. 2002. First report of pectenotoxin-2 in isolated Dinophysis caudata cells determined by liquid chromatography-mass spectrometry. In X International Conference on Harmful Algae, St. Pete Beach, Florida, USA, October 21—25, 2002, Book of Abstracts, p. 91. 

Over 30 years of liquid chromatography-mass spectrometry (LC-MS) research has resulted in a considerable number of different interfaces (Ch. 3.2). A variety of LC-MS interfaces have been proposed and built in the various research laboratories, and some of them have been adapted by instmment manufacturers and became commercially available. With the advent in the early 1990 s of interfaces based on atmospheric-pressure ionization (API), most of these interfaces have become obsolete. However, in order to appreciate LC-MS, one carmot simply ignore these earlier developments. This chapter is devoted to the older LC-MS interfaces, which is certainly important in understanding the histoiy and development of LC-MS. Attention is paid to principles, instrumentation, and application of the capillary inlet, pneumatic vacuum nebulizers, the moving-belt interface, direct liquid introduction, continuous-flow fast-atom bombardment interfaces, thermospray, and the particle-beam interface. More elaborate discussions on these interfaces can be found in previous editions of this book. 

Hyphenated methods such as gas chromatography-mass spectrometry (GC-MS) or liquid chromatography-mass spectrometry (LC-MS) and a number of other chromatographic and spectroscopic configurations are perfectly suitable for initial characterization of the impurities. Of course, these methods are not always applicable, especially when the authentic material is needed for purposes of structure confirmation, synthesis, or toxicity studies (this subject is discussed in various chapters of this book also see reference 2). 

Several excellent reviews and books on the development of LC/MS have already been written [1—13] and are recommended as resources. The applications of liquid chromatography to mass spectrometry, using techniques such as particle... 

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