Clinical liquid chromatography mass spectrometry

P. Marquet. Progress of Liquid Chromatography-Mass Spectrometry in Clinical and Forensic Toxicology, Therapeutic Drug Monitoring, 24, no. 2, (2002). 

Li C, Hong Y, Tan YX et al. Accurate qualitative and quantitative proteomic analysis of clinical hepatocellular carcinoma using laser capture microdissection coupled with isotope-coded affinity tag and two-dimensional liquid chromatography mass spectrometry. Mo/ Cell Proteomics 2004,3399-409. 

Maurer, H. H. (2007). Current role of liquid chromatography-mass spectrometry in clinical and forensic toxicology. Anal. Bioanal. Chem. 388 1315-1325. 

Atomic absorption spectrometry with flame (AA-F) or electrothermal atomization furnace (AA-ETA), inductively coupled plasma-emission spectroscopy (ICP-ES), inductively coupled plasma-mass spectrometry (ICP-MS), and high-performance liquid chromatography-mass spectrometry (LC-MS) are state-of-the-art analytical techniques used to measure metals in biological fluids. They are specific and sensitive and provide the cfinical laboratory with the capability to measure a broad array of metals at clinically significant concentrations. For example, ICP-MS is used to measure several metals simultaneously. Photometric assays are also available but require large volumes of sample and have limited analytical performance. Spot tests are also... 

See also Capillary Electrochromatography. Capillary Electrophoresis Pharmaceutical Applications Low-Molecular-Weight Ions Food Chemistry Applications Clinical Applications. Extraction Solid-Phase Extraction Solid-Phase Microextraction. Gas Chromatography Mass Spectrometry. Liquid Chromatography Overview Liquid Chromatography-Mass Spectrometry. 

Maurer HH (1998) Liquid chromatography-mass spectrometry in forensic and clinical toxicology. Journal of... 

See a/so Clinical Analysis Sample Handling. Gas Chromatography Mass Spectrometry. Liquid Chromatography Liquid Chromatography-Mass Spectrometry. Mass Spectrometry Ionization Methods Ovenriew Atmospheric Pressure Ionization Techniques Time-of-Flight Selected Ion Monitoring Stable Isotope Ratio. Peptides. Proteins Traditional Methods of quence Determination. Quality Assurance Internal Standards. 

During the last decade, the use of liquid chromatography-mass spectrometry (LC-MS) technology has been increasing in clinical and forensic laboratories. This expansion is in part because of the gradual introduction of relatively low-cost LC-MS instruments and the availability of robust atmospheric pressure ionization (API) sources. The combination of liquid chromatographic separation and mass spectrometric detection provides the laboratory an efficient... 

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