High-performance liquid chromatography with mass spectrometry

What are the Advantages of Linking High Performance Liquid Chromatography with Mass Spectrometry ... [Pg.20]

Vlase, L., Imre, S., Muntean, D., and Leucuta, S. E. (2007). Determination of loratadine and its active metabolite in human plasma by high-performance liquid chromatography with mass spectrometry detection. J. Pharm. Biomed. Anal. 44 652-657. [Pg.82]

High-performance liquid chromatography with mass spectrometry detection has been applied to the analysis of compounds such as azo dyes in wastewater, trace levels of pesticides in water, and picogram levels of... [Pg.106]

Guillarme, D., Schappler, J., Rudaz, S., and Veuthey, J. L. 2010. Coupling ultra-high-performance liquid chromatography with mass spectrometry. Trends Anal. Chem. 29 15-27. [Pg.386]

The coupling of high-performance liquid chromatography with mass spectrometry (HPLC-MS) has become a very important tool for the reliable identification and quantification of complex samples. In the pharmaceutical industry, for instance, the metabolic pathways or pharmacological effects of new products are often studied with this system. [Pg.307]

In this chapter, the reader has been introduced to the analytical advantages to be gained by linking high performance liquid chromatography to mass spectrometry with particular regard to the limitations of the two techniques when they are used independently. [Pg.23]

To understand the principles of operation of each of these interfaces, in particular with regard to the way in which they achieve compatibility between high performance liquid chromatography and mass spectrometry. [Pg.133]

Karlsson AA, Michelsen P, Odham G. 1998. Molecular species of sphingomyelin determination by high-performance liquid chromatography/mass spectrometry with electrospray and high-performance liquid chromatography/tandem mass spectrometry with atmospheric pressure chemical ionization. J Mass Spectrom 33 1192. [Pg.171]

Yu, K., Little, D., Plumb, R., and Smith, B. (2006). High-throughput quantification for a drug mixture in rat plasma—A comparison of ultra performance liquid chromatography/tandem mass spectrometry with high-performance liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 20 544-552. [Pg.84]

Hager, J. W., and Le Blanc, J. C. (2003). High-performance liquid chromatography-tandem mass spectrometry with a new quadrupole/linear ion trap instrument. J. Chromatogr. A 1020 3-9. [Pg.156]

Farre, M. 2006. Evaluation of commercial immunoassays for the detection of estrogens in water by comparison with high-performance liquid chromatography tandem mass spectrometry HPLC-MS/MS (QqQ)-Anal. Bioanal. Chem. 385 1001. [Pg.185]

Micro-solid phase extraction coupled with high-performance liquid chromatography-tandem mass spectrometry for the determination of stimulants, hallucinogens, ketamine and phencyclidine in oral fluids. Anal Chim Acta 675(2) 132-137. doi 10.1016/j.aca.2010.07.011... [Pg.393]

Maralikova B, Weinmann W (2004) Confirmatory analysis for drugs of abuse in plasma and urine by high-performance liquid chromatography-tandem mass spectrometry with respect to criteria for compound identification. J Chromatogr B Analyt Technol Biomed Life Sci 811(1) 21—30. doi 10.1016/j.jchromb.2004.04.039 SI570-0232(04)00642-7 [pii]... [Pg.393]

Magiera, S., Giilmez, S. Ultrasound-assisted emulsification microextraction combined with ultra-high performance liquid chromatography-tandem mass spectrometry for the analysis of ibuprofen and its metabolites in human urine. J. Pharm. Biomed. Anal. 92, 193-202 (2014)... [Pg.278]

High-performance liquid chromatography-tandem mass spectrometry method for the determination of gemifloxacin in human plasma was based on the protein precipitation of plasma samples with acetonitrile containing [ C Ha] gemifloxacin as an internal standard. The supernatant was injected onto a PLRP-S column without any further clean-up. The mass spectrometer was operated in positive ion mode, and the ions were detected in multiple reaction-monitoring (MRM) mode. The assay requires 50 gl of plasma and is precise and accurate within the range 10-5000 ng/ml [15]. [Pg.163]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...