Isotope dilution with liquid chromatography mass

Chen Y., Wang C., and Wu K., 2005. Analysis of N7-(benzo[a]pyrene-6-yl)guanine in urine using two-step solid-phase extraction and isotope dilution with liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 19 893. 

See also Atomic Absorption Spectrometry Interferences and Background Correction. Atomic Emission Spectrometry Principles and Instrumentation Interferences and Background Correction Flame Photometry Inductively Coupled Plasma Microwave-Induced Plasma. Atomic Mass Spectrometry Inductively Coupled Plasma Laser Microprobe. Countercurrent Chromatography Solvent Extraction with a Helical Column. Derivatization of Analytes. Elemental Speciation Overview Practicalities and Instrumentation. Extraction Solvent Extraction Principles Solvent Extraction Multistage Countercurrent Distribution Microwave-Assisted Solvent Extraction Pressurized Fluid Extraction Solid-Phase Extraction Solid-Phase Microextraction. Gas Chromatography Ovenriew. Isotope Dilution Analysis. Liquid Chromatography Ovenriew. 

Table 1. Analysis characteristics for the assay of dicarbonyl compounds by derivatisation with 1,2-diaminobenzene and stable isotopic dilution analysis liquid chromatography - tandem mass spectrometry.

Tai SS, Welch MJ. 2000. Determination of ll-nor-delta9-tetrahydrocannabinol-9-carboxylic acid in a urine-based standard reference material by isotope-dilution liquid chromatography-mass spectrometry with electrospray ionization. J Anal Toxicol 24 385. 

Heumann, K.G., Rottmann, L. and Vogl, J. (1994) Elemental speciation with liquid-chromatography inductively-coupled plasma isotope-dilution mass-spectrometry. /. Anal. At. Spectrom., 9, 1351-1355. 

Chao M. et al., 2005. Rapid and sensitive quantification of urinary N7-mthelguanine by isotope-dilution liquid chromatography/electrospray ionization tandem mass spectrometry with online solid-phase extraction. Rapid Commun Mass Spectrom 19 2427. 

Hu C. et al., 2006. Clinical-scale high-throughput analysis of urinary 8-oxo-7,8-dihydro-2 -deoxyquanosine by isotope-dilution liquid chromatography-tandem mass spectrometry with online sohd-phase extraction. Clin Chem 52 7. 

Clarke, D.B., Lloyd, A.S., Botting, N.P., Oldfield, M.F., Needs, P.W., and Wiseman, H., Measurement of intact sulfate and glucuronide phytoestrogen conjugates in human urine using isotope dilution liquid chromatography-tandem mass spectrometry with [13C(3)]isoflavone internal standards, Anal. Biochem., 309, 158, 2002. 

Rodriguez-Cabaleiro D, van Uytfanghe K, Stove V, Fiers T, Thienpont LM (2007) Pilot study for the standardization of insulin immunoassays with isotope dilution liquid chromatography/ tandem mass spectrometry. Clin Chem 53 1462-1469... 

Gambert, P., Lallemant, C., Archambault, A., Maume, B. F., and Padieu, P. (1979). Assessment of serum cholesterol by two methods gas liquid chromatography on capillary columns and chemical ionisation mass fragmentography with isotope dilution of 3,4-13C-cholesterol as internal standard. J. Chromatogr. 162, 1-6. 

Figure 4 Schematic diagram of high-pressure liquid chromatography inductively coupled plasma mass spectrometry (HPLC-ICP-MS) system with dual-inlet system for isotope dilution analyses. (From Ref. 32.)...

Thienpont LM, Verhaeghe PG, Van Brussel KA, De Leenheer AP. Estradiol-17 beta quantified in serum by isotope dilution-gas chromatography-mass spectrometry reversed-phase C18 high-performance liquid chromatography compared with immuno-affinity chromatography for sample pretreatment. Clin Chem 1988 34 2066-9. 

E., and Dedon, P.C. (2008) Quantification of DNA damage products resulting from deamination, oxidation and reaction with products of lipid peroxidation hy liquid chromatography isotope dilution tandem mass spectrometry. Nat. Protoc., 3,1287-1298. 

The qualitative and quantitative determinations of morphinane alkaloids or their derivatives in opium were studied by application of different methods (278, 533, 534), by differentia] spectrophotometry (535, 536), thin-layer chromatography (509, 537, 538), gas chromatography in conjunction with mass spectrometry (539, 540), and high-speed liquid chromatography (thebaine) (327, 534). A procedure for the quantitative determination of morphine in opium by isotopic dilution has been developed (541). 

Mohamed R, Hammel YA, LeBreton MH, Tabet JC, Jullien L, Guy PA, Evaluation of atmospheric pressure ionization interfaces for quantitative measurement of sulfonamides in honey using isotope dilution liquid chromatography coupled with tandem mass spectrometry techniques, J. Chromatogr. A 2007 1160(l-2) 194-205. 

Riediker, S., and Stadler, R. H. 2003. Analysis of acrylamide in food using isotope-dilution liquid chromatography coupled with electrospray ionization tandem mass spectrometry, J. Chrom. A., 1020 121—130. 

Zhang, Y, Ren, Y, Zhao, H., and Zhang, Y. 2007. Determination of acrylamide in Chinese traditional carbohydrate-rich foods using gas chromatography with microelectron capture detector and isotope dilution liquid chromatography combined with electrospray ionization tandem mass spectrometry. Anal. Chim. Acta. 584 322-332. 

Methods also employed for determination of inorganic lead include isotope dilution mass spectrometry, flame atomic fluorescence spectrometry, and molecular absorption spectrometry, but these methods are not used for routine applications. Methods for the determination of organolead speciation are high-performance liquid chromatography with a separation of the species and flame AAS or UV detection. 

Assessment of Serum Cholesterol by Two Methods Gas-Liquid Chromatography on a Capillary Column and Chemical Ionization-Mass Fragmentography with Isotopic Dilution [3,4- C]-Cholesterol as Internal Standard J. Chromatogr. 162(1) 1-6 (1979) CA 1348. 90 50804u... 

A 96-well microtitre plate assay with microcomputer analysis has simplified the microbiological assay making it less laborious, less time-consuming and more reproducible. Recently, an automated 96-well plate isotope-dilution tandem mass spectrometry method and an ultra-performance liquid chromatography-tandem mass spectrometry method have been developed and validated for the quantification of synthetic folic add in folate-fortified breads (Fazili and Pfeiffer 2004 Chandra-Hioe et al. 2011). 

Table 19.3 Results of niacin determinations for milk samples. Niacin determinations by liquid chromatography-isotope dilution mass spectrometry (LC-IDMS) are compared to expected values for four milk samples. Expected niacin levels for milk are roughly 1 ppm, according to the USDA Nutrient Database for Standard Reference (US Department of Agriculture 2010) and results obtained for two commercial milk samples (Brands F and G) are a little under 1 ppm. The result for sample NFY0409F6 is about 30% lower, but is consistent with results obtained for other milk samples from the same source. In addition, the niaein level for NFY0409F6 was estimated by a standard additions experiment, the result from which is in agreement with the estimate from the normal LC-IDMS procedure. The level obtained for the reference material (RM) RM 8435 whole milk powder, reported on a dry mass basis, is in agreement with the reference value. Data are from Goldschmidt and Wolf (2007), with permission from the publisher.

Kock, R. Delvoux, B. Tilhnanns, U. Greiling, H. A candidate reference method for the determination of uric acid in serum based on high-performance liquid chromatography, compared with an isotope dilution-gas chromatography-mass spectrometer method. J. CUn. Chem. Clin. Biochem. 1989, 27, 157-162. 

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