Liquid chromatography - mass spectrometr properties

The selection of methods used in the determination of persistent organic contaminants depends on the physical and chemical properties of the analytes imder study. Liquid chromatography is often well suited to applications that are not compatible with gas chromatography, and LC is the preferred method for the determination of POPs that are polar, thermally labile, or isomeric. Mass spectrometric detection is essential to achieve sufficient specificity and sensitivity for trace level analysis of complex matrix environmental samples. CRMs and SRMs serve as useful tools in the development and validation of new methods, as control materials in quality assurance, and in instrument calibration. Proper use of reference materials can also support claims of measurement traceability. 

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