Liquid chromatography-mass analysis

Very little in the way of advances has occurred since 1971 in the applications of ultraviolet or infrared spectroscopy to the analysis of fluonnated organic compounds Therefore, only gas-liquid chromatography, liquid chromatography, mass spectrometry, and electron scattering for chemical analysis (ESCA) are discussed The application of nuclear magnetic resonance (NMR) spectroscopy to the analysis of fluonnated organic compounds is the subject of another section of this chapter... [Pg.1029]

The ion spray liquid chromatography/mass spectrometry (LC-MS) interface coupled via a postsuppressor split with an ion chromatography (IC) has been used in the analysis of alcohol sulfates. The IC-MS readily produces the molecular weight while the tandem mass spectrometric detection IC-MS-MS provides structural information [305]. [Pg.285]

Anacleto, J. F., QuiUiam, M. A. and Boyd, R. K., Analysis of fuUerene soot extracts by liquid chromatography-mass spectrometry using atmospheric pressure ionization , in Proceedings of the 41st ASMS Conference on Mass Spectrometry and Allied Topics, San Francisco, CA, May 30-June 4, 1993, p. 1083. [Pg.185]

Figure 5.6 Positive-ion electrospray spectrum obtained from the major component in the LC-MS analysis of a purified recombinant 62 kDa protein using a Cig microbore 50 X 1 mm column and a flow rate of 50 p.lmin . The starting buffer (buffer A ) was 0.1% TEA in water, while the gradient buffer (buffer B ) consisted of 0.1% TEA in acetonitrile-water (9 1 vol/vol). The running conditions consisted of 0% B for 5 min, followed by a linear gradient of 100% B for 55 min. Reprinted from J. Chromatogr., B, 685, McAtee, C. P., Zhang, Y., Yarbough, P. O., Fuerst, T. R., Stone, K. L., Samander, S. and Williams, K. R., Purification and characterization of a recombinant hepatitis E protein vaccine candidate by liquid chromatography-mass spectrometry , 91-104, Copyright (1996), with permission from Elsevier Science.

Betowski LD, Jones TL. 1988. Analysis of organophosphoms pesticide samples by high-performance liquid chromatography/mass spectrometry and high-performance liquid chromatography/mass spectrometry/mass spectrometry. Environ Sci Technol 22 1430-1434. [Pg.195]

LAZARUS s E, ADAMSON G E, HAMMERSTONE J F and SCHMITZ H H (1999) High-performance liquid chromatography/Mass spectrometry analysis of proanthocyanidins in foods and beverages, JAgric Food Chem, 47, 3693-701. [Pg.343]

Paganga, G. et al.. The polyphenolic content of fruit and vegetables and their antioxidant activities what does a serving constitute Free Radical Res., 30, 153, 1999. Maatta, K.R. et al.. High-performance liquid chromatography (HPLC) analysis of phenolic compounds in berries with diode array and electrospray ionization mass spectrometric (MS) detection Rihes species, J. Agric. Food Chem., 51, 6736, 2003. [Pg.84]

Several methods can be used for the residue analysis of anilides, especially gas chro-matography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS). GC/ECD or GC/NPD for the determination of anilides has generally been used except for the unstable metabolites of naproanilide and clomeprop, which are determined by HPLC/UV, HPLC/FL or GC/ECD after derivatization. [Pg.332]

More recently, liquid chromatography/mass spectrometry (LC/MS) and liquid chromatography/tandem mass spectrometry (LC/MS/MS) have been evaluated as possible alternative methods for carfentrazone-ethyl compounds in crop matrices. The LC/MS methods allow the chemical derivatization step for the acid metabolites to be avoided, reducing the analysis time. These new methods provide excellent sensitivity and method recovery for carfentrazone-ethyl. However, the final sample extracts, after being cleaned up extensively using three SPE cartridges, still exhibited ionization suppression due to the matrix background for the acid metabolites. Acceptable method recoveries (70-120%) of carfentrazone-ethyl metabolites have not yet been obtained. [Pg.488]

Several determination methods such as GC, HPLC, gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS) are used for the analysis of neonicotinoid residues. The applications of GC/MS and LC/MS are of increasing importance. The application of HPLC to the determination of neonicotinoids residues is limited, especially when metabolites (such as acetamiprid and nitenpyram) can be easily determined by GC after derivatization. [Pg.1133]

Liquid chromatography/mass spectrometry (LC/MS) analysis Quantitation system Agilent Series 1100 liquid chromatograph Chromsep Omnispher 3 Cig HPLC column, 100 x 4.6-mm i.d., 3- am diameter particle size... [Pg.1179]

Two variations on the analysis of PCR products by ESI mass spectrometry have emerged (1) direct-injection MS and tandem mass spectrometry (MS-MS) and (2) liquid chromatography-mass spectrometry (LC-MS) and tandem mass spectrometry (LC-MS/MS). In the former approach, the sample is cleaned manually, and as noted above, the cleanup is performed as simply and rapidly as possible. In the latter approach, the cleanup is done automatically... [Pg.29]

Llorca M, Farre M, Pico Y, Barcelo D (2011) Analysis of perfluorinated compounds in sewage sludge by pressurized solvent extraction followed by liquid chromatography-mass spectrometry. J Chromatogr A 1218(30) 4840 1846... [Pg.45]

Petrovic M, Farre M, de Alda ML, Perez S, Postigo C, Kock M, Radjenovic J, Gros M, Barcelo D (2010) Recent trends in the liquid chromatography-mass spectrometry analysis of organic contaminants in environmental samples. J Chromatogr A 1217(25) 4004 1017... [Pg.46]

Jaitly, N., Monroe, M.E., Petyuk, V.A., Clauss, T.R.W., Adkins, J.N., Smith, R.D. (2006). Robust algorithm for alignment of liquid chromatography-mass spectrometry analyses in an accurate mass and time tag data analysis pipeline. Anal. Chem. 78, 7397-7409. [Pg.32]

Opiteck, G.J., Jorgenson, J.W., MacNair, J.E., Moseley, M.A., 3rd (1997). Two-dimensional SEC/RPLC coupled to mass spectrometry for the analysis of peptides. Rapid separation and characterization of protein and peptide mixtures using 1.5 microns diameter non-porous silica in packed capillary liquid chromatography/mass spectrometry. Anal. Chem. 69, 2283-2291. [Pg.287]

AmMa J, Yang H, Basile MJ and Kennelly EJ. 2004. Analysis of polyphenolic antioxidants from the fruits of three Pouteria species by selected ion monitoring liquid chromatography/mass spectrometry. J Agric... [Pg.44]

Im HW, Suh BS, Lee SU, Kozukue N, Ohnisi-Kameyama M, Levin CE and Friedman M. 2008. Analysis of phenolic compounds by high-performance liquid chromatography and liquid chromatography/mass spectrometry in potato plant flowers, leaves, stems, and tubers and in home-processed potatoes. J Agric Food Chem 56(9) 3341-3349. [Pg.83]

Wuhrer, M., Koeleman, C.A., Hokke, C.H., and Deelder, A.M. 2005. Protein glycosylation analysis by liquid chromatography-mass spectrometry. Journal of Chromatography B 825, 124-133. [Pg.203]

Keywords Ebro River, Illicit drugs, Liquid chromatography, Mass spectrometry, Surface water, Wastewater, Water analysis... [Pg.190]

WATSON, D.G., PITT, A.R., Analysis of flavonoids in tablets and urine by gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry, Rapid Comm. Mass Spectrom., 1998,12,153-156. [Pg.195]

High-Throughput Quantitative Pharmaceutical Analysis in Drug Metabolism and Pharmacokinetics Using Liquid Chromatography-Mass Spectrometry... [Pg.319]

Ferrer I, Thurman EM (eds) (2003) Liquid chromatography-mass spectrometry/mass spectrometry, MS/MS and time-of-flight MS analysis of emerging contaminants. American Chemical Society Symposium Series 850, Oxford University Press, Washington... [Pg.75]

Other combinations are available. For example, liquid chromatographs connected to mass spectrometers (known as liquid chromatography-mass spectrometry [LC-MS]) are fairly common. Almost any combination of two instruments that can be thought of has been built. In addition, two of the same instruments can be connected so that the output from one is fed directly into the other for further separation and analysis. Examples include two mass spectrometers in an MS-MS arrangement and two different gas chromatography columns connected in a series, known as GC-GC. To keep up with these advances, one needs to have a working knowledge of the fundamental principles involved in the techniques and of the abbreviations used for the various instrumentation methods. [Pg.32]

Chromatographic methods are also often used as part of systems that are called hyphenated methods, (see Chapter 15) where the output of the chromatographic section is used as the input for an identification method such as mass spectrometry. These hyphenated methods are also most often referred to by their acronyms, for example, GC-MS—gas chromatography-mass spectrometry and HPLC-MS—high-performance liquid chromatography-mass spectrometry. Note that although ultraviolet-visible (UV-Vis) is hyphenated, it is not a hyphenated method in that it does not consist of two different methods of analysis. Hyphenated methods will be discussed fully in Chapter 15. [Pg.272]

R.P.W. Scott, C.G. Scott, M. Munroe and J. Hess Jr., Interface for on-line liquid chromatography-mass spectroscopy analysis, J. Chromatogr., 99 (1974) 395-405. [Pg.751]

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