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Liquid chromatography-mass metabolite quantitation

LC/MS/MS. LC/MS/MS is used for separation and quantitation of the metabolites. Using multiple reaction monitoring (MRM) in the negative ion electrospray ionization (ESI) mode, LC/MS/MS gives superior specificity and sensitivity to conventional liquid chromatography/mass spectrometry (LC/MS) techniques. The improved specificity eliminates interferences typically found in LC/MS or liquid chro-matography/ultraviolet (LC/UV) analyses. Data acquisition is accomplished with a data system that provides complete instmment control of the mass spectrometer. [Pg.383]

Bakhtiar, R., and Majumdar, T. K. (2007). Tracking problems and possible solutions in the quantitative determination of small molecule chugs and metabolites in biological fluids using liquid chromatography-mass spectrometry. J. Pharmacol. Toxicol. Methods 55 227-243. [Pg.64]

Lant, M. S. Martin, L. E. Oxford, J. 1985. Qualitative and quantitative analysis of ranitidine and its metabolites by high-performance liquid chromatography-mass spectrometry. /. Chromatogr., 323,143-152. [Pg.220]

Xu X, Keefer LK, Ziegler RG, Veenstra TD (2007) A liquid chromatography-mass spectrometry method for the quantitative analysis of urinary endogenous estrogen metabolites. Nat Protoc 2 1350-1355... [Pg.284]

Yu, C. et al., A rapid method for quantitatively estimating metabolites in human plasma in the absence of synthetic standards using a combination of liquid chromatography/ mass spectrometry and radiometric detection, Rapid Commun. Mass Spectrom., 21(4), 497, 2007. [Pg.196]

Valaskovic, G.A. et al., Ultra-low flow nanospray for the normalization of conventional liquid chromatography/mass spectrometry through equimolar response Standard-free quantitative estimation of metabolite levels in drug discovery, Rapid Commun. Mass Spectrom., 20, 1087, 2006. [Pg.253]

Tracqui, A. Kintz, R Mangin, R Lugnier, A.A. Chaumont, A.J. A new rapid HPLC assay for the simultaneous determination of two histamine H2-receptor antagonists, cimetidine and ranitidine, in human plasma. J.Toxicol.CUn.Exp., 1988, 8, 387-394 Lant, M.S. Martin, L.E. Oxford, J. Qualitative and quantitative analysis of ranitidine and its metabolites by high-performance liquid chromatography-mass spectrometry. J.Chromatogr., 1985, 323, 143-152 [UV detection LC-MS]... [Pg.1222]

Ranalder, U.B. Lausecker, B.B. Huselton, C. Micro liquid chromatography-mass spectrometry with direct Uquid introduction used for separation and quantitation of all-(rans- and 13-cis-retinoic acids and their 4-oxo metabolites in human plasma. J.Chromatogr., 1993, 617, 129-135 [LC-MS LOQ 0.3 ng/mL extracted metabolites, isotretinoin, tretinoin]... [Pg.1233]

Wu, H., J. Guo, S. Chen et al. 2013. Recent developments in qualitative and quantitative analysis of phytochemical constituents and their metabolites using liquid chromatography-mass spectrometry./. Pharm. Biomed. Anal. 72 267-291. [Pg.423]

Dear, G.J., Fraser, I.J., Patel, D.K., Long, J., and Pleasance, S., Use of liquid chromatography-tandem mass spectrometry for the quantitative and qualitative analysis of an antipsychotic agent and its metabolites in human plasma and urine, /. Chromatogr. A, 794, 27, 1998. [Pg.67]

Draisci R, Pallaeschi L, Ferretti E, Lucentini L, Cammarata P. 2000. Quantitation of anabolic hormones and their metabolites in bovine serum and urine by liquid chromatography-tandem mass spectrometry. J Chromatogr A 870(1-2) 511-522. [Pg.37]

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