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Liquid chromatography/mass spectrometry processing

Drexler, D.M. et al., An automated high throughput liquid chromatography-mass spectrometry process to assess the metabolic stability of drug candidates, Assay Drug Dev. Technol., 5(2), 247, 2007. [Pg.192]

McNaney CA, Drexler DM, Hnatyshyn SY, Zvyaga TA, Knipe JO, Belcastro JV, Sanders M. An automated liquid chromatography—mass spectrometry process to determine metabolic stability half-life and intrinsic clearance of drug candidates by substrate depletion. Assay Drug Dev Technol 2008 6(1) 121—129. [Pg.404]

Ethylenethiourea (ETU) is a toxic decomposition product/metabolite of alky-lenebis(dithiocarbamates). This compound could be generated during processing of treated crops at elevated temperature. Different chromatographic methods to determine the residue levels of ETU have been published. After extraction with methanol, clean-up on a Gas-Chrom S/alumina column and derivatization (alkylation) with bro-mobutane, ETU residues can be determined by GC with a flame photometric detector in the sulfur mode. Alternatively, ETU residues can also be determined by an HPLC method with UV detection at 240 nm or by liquid chromatography/mass spectrometry (LC/MS) or liquid chromatography/tandem mass spectrometry (LC/MS/MS) (molecular ion m/z 103). ... [Pg.1091]

Im HW, Suh BS, Lee SU, Kozukue N, Ohnisi-Kameyama M, Levin CE and Friedman M. 2008. Analysis of phenolic compounds by high-performance liquid chromatography and liquid chromatography/mass spectrometry in potato plant flowers, leaves, stems, and tubers and in home-processed potatoes. J Agric Food Chem 56(9) 3341-3349. [Pg.83]

Internal reflection spectroscopy is widely applied for on-line process control. In this type of application, the chemical reactor is equipped with an internal reflection probe or an IRE. The goal of this type of application is the quantification of reactant and/or product concentrations to provide real-time information about the conversion within the reactor. In comparison with other analytical methods such as gas chromatography, high-pressure liquid chromatography, mass spectrometry, and NMR spectroscopy, ATR spectroscopy is considerably faster and does not require withdrawal of sample, which can be detrimental for monitoring of labile compounds and for some other applications. [Pg.242]

Hong YJ, Barrett DM, Mitchell AE. 2004. Liquid chromatography/mass spectrometry investigation of the impact of thermal processing and storage on peach procyanidins. J Agric Food Chem 52 2366-2371. [Pg.43]

Li H.Q., F. Jiku, and H.F. Schroder. 2000. Assessment of the pollutant elimination efficiency by gas chromatography/mass spectrometry, liquid chromatography-mass spectrometry and—tandem mass spectrometry comparison of conventional and membrane-assisted biological wastewater treatment processes. J. Chromatogr. A 889 155-176. [Pg.349]

XCMS Scripps Center for Metabolomics Software for processing liquid chromatography-mass spectrometry-based metabolomics data (http //medin.scripps.edu/... [Pg.27]

To investigate the complex metabolic consequences of disease processes, toxic reactions, and genetic manipulation, nonselective but specific analytical approaches are required. Several spectroscopic methods in addition to nuclear magnetic resonance (NMR) can produce metabolic signatures of biomaterials, including mass spectrometry (MS), gas chromatography/mass spectrometry (GC/MS), liquid chromatography/mass spectrometry (LC/MS), liquid... [Pg.1626]

Lehr, G. J., Barry, T. L., Petzinger, G., Hanna, G. M. and Zito, S. W. Isolation and identification of process impurities in trimethoprim drug substance by high-performance liquid chromatography, atmospheric pressure chemical ionization liquid chromatography/ mass spectrometry and nuclear magnetic resonance spectroscopy. J. Pharm. Biomed. Anal. 19 373-389, 1999. [Pg.295]

Liquid chromatography-mass spectrometry (LC-MS) ideally combines advantages of the gentle separation of HPLC with high sensitivity and selectivity of mass spectrometry. There are two methods of ionization. The electrospray LC-MS ionization process can effectively transform the heterocychc amines from solution to protonated ions in the gas phase. The thermospray LC-MS ionization process produces abundant pseudo-molecular ions for this class of compounds. As a result, in both ionization processes the base peaks in the mass spectra are... [Pg.392]

Kostiainen R, Kauppila TJ, Effect of eluent on the ionization process in liquid chromatography-mass spectrometry, J. Chromatogr. A 2009 1216(4) 685-699. [Pg.221]

Fredriksson M, Petersson P, Jornten-Karlsson M, Axelsson BO, Bylund D. An objective comparison of pre-processing methods for enhancement of liquid chromatography-mass spectrometry data. J Chromatogr A 2007 1172 135—150. [Pg.442]

Fleming CM, et al. Windowed mass selection method A new data processing algorithm for liquid chromatography—mass spectrometry data. J Chromatogr A 1999 849 71-85. [Pg.717]

Hastings CA, et al. New algorithms for processing and peak detection in liquid chromatography/mass spectrometry data. Rapid Commun Mass Spectrom... [Pg.718]

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See also in sourсe #XX -- [ Pg.110 , Pg.328 ]



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