Liquid chromatography-mass spectrometry resonance

Very little in the way of advances has occurred since 1971 in the applications of ultraviolet or infrared spectroscopy to the analysis of fluonnated organic compounds Therefore, only gas-liquid chromatography, liquid chromatography, mass spectrometry, and electron scattering for chemical analysis (ESCA) are discussed The application of nuclear magnetic resonance (NMR) spectroscopy to the analysis of fluonnated organic compounds is the subject of another section of this chapter... [Pg.1029]

The system relies upon preliminary fractionation of the microbial crude extract by dualmode countercurrent chromatography coupled with photodiode array detection (PDA). The ultraviolet-visible (UV-Vis) spectra and liquid chromatography-mass spectrometry (LC-MS) of biologically active peaks are used for identification. Confirmation of compound identity is accomplished by nuclear magnetic resonance (NMR). Use of an integrated system countercurrent chromatography (CCC) separation, PDA detection, and LC-MS rapidly provided profiles and structural information extremely useful for metabolite identification (dereplication, Figure 14.1). [Pg.191]

Abbreviations DCM, dichloromethane DIC, 1,3-diisopropylcarbodiimide DIEA, diiso-propylethylamine DMAP, 4-dimethylaminopyridine DMF, IVJV-dimethylformamide ELSD, evaporative light scattering detection HOBt, hydroxybenzotriazole IR, infrared LC/MS, high-pressure liquid chromatography/mass spectrometry NMM, V-methylmorpho-line NMR, nuclear magnetic resonance PyBop, benzotriazol-l-yloxytripyrrolidino-phosphonium hexafluorophosphate SAR, structure-activity relationship TFP, tetrafluorophenol THF, tetrahydrofuran. [Pg.151]

Kosir IJ, Lapornik B, Andrensek S, Wondra AG, Vrhovsek U and Kidric J, Identification of anthocyanins in wines by liquid chromatography, liquid chromatography-mass spectrometry and nuclear magnetic resonance. Anal Chim Acta 513 277-282 (2004). [Pg.74]

LC/MS/NMR Liquid Chromatography/Mass Spectrometry/Nuclear Magnetic Resonance Spectroscopy... [Pg.160]

Dear GJ, Plumb RS, Sweatman BC et al. (2000) Mass directed peak selection, an efficient method of drug metabolite identification using directly coupled liquid chromatography-mass spectrometry-nuclear magnetic resonance spectroscopy. J Chromatogr B Biomed Sci Appl 748 281-293... [Pg.502]

G. J. Dear, R. S. Plumb, B. C. Sweatman, P. S. Parry, A. D. Roberts, J. C. Lindon, J. K. Nicholson, and I. M. Ismail, Use of directly coupled ion-exchange liquid chromatography-mass spectrometry and liquid chromatography-nuclear magnetic resonance spectroscopy as a strategy for polar metabolite identification, J. Chro-... [Pg.933]

Mutlib AE, Chen H, Nemeth G, et al. Liquid chromatography/mass spectrometry and high-field nuclear magnetic resonance characterization of novel mixed diconjugates of the non-nucleoside human immunodeficiency virus-1 reverse transcriptase inhibitor, efavirenz. Drug Metab Dispos. 1999 27(9) 1045-1056. [Pg.243]

To investigate the complex metabolic consequences of disease processes, toxic reactions, and genetic manipulation, nonselective but specific analytical approaches are required. Several spectroscopic methods in addition to nuclear magnetic resonance (NMR) can produce metabolic signatures of biomaterials, including mass spectrometry (MS), gas chromatography/mass spectrometry (GC/MS), liquid chromatography/mass spectrometry (LC/MS), liquid... [Pg.1626]

Lehr, G. J., Barry, T. L., Petzinger, G., Hanna, G. M. and Zito, S. W. Isolation and identification of process impurities in trimethoprim drug substance by high-performance liquid chromatography, atmospheric pressure chemical ionization liquid chromatography/ mass spectrometry and nuclear magnetic resonance spectroscopy. J. Pharm. Biomed. Anal. 19 373-389, 1999. [Pg.295]

LC-MS-NMR liquid chromatography-mass spectrometry-nuclear magnetic resonance... [Pg.588]

D. High-Performance Liquid Chromatography/Mass Spectrometry and High-Performance Liquid Chromatography/Nuclear Magnetic Resonance... [Pg.345]