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Liquid chromatography—mass determination

A liquid chromatography-mass spectrometry (LC-MS) method that can quantitatively analyze urinar y normal and modified nucleosides in less than 30 min with a good resolution and sufficient sensitivity has been developed. Nineteen kinds of normal and modified nucleosides were determined in urine samples from 10 healthy persons and 18 breast cancer patients. Compounds were separ ated on a reverse phase Kromasil C18 column (2.1 mm I.D.) by isocratic elution mode using 20 mg/1 ammonium acetate - acetonitrile (97 3 % v/v) at 200 p.l/min. A higher sensitivity was obtained in positive atmospheric pressure chemical ionization mode APCI(-i-). [Pg.351]

G. S. Rule, A. V. Moi dehai and J. Henion, Determination of carbofuran by on-line immunoaffinity cliromatography with coupled-column liquid chromatography/mass spectrometiy . Aim/. Chem. 66 230-235 (1994). [Pg.132]

Hummel D, Loffler D, Fink G, Temes TA (2006) Simultaneous determination of psychoactive drugs and their metabolites in aqueous matrices by liquid chromatography mass spectrometry. Environ Sci Technol 40 7321-7328... [Pg.225]

Farre M, Ferrer I, Ginebreda A, Figueras M, Olivella L, Tirapu L, Vilanova M, Barcelo D (2001) Determination of drugs in surface water and wastewater samples by liquid chromatography-mass spectrometry methods and preliminary results including toxicity studies with Vibrio fischeri. J Chromatogr A 938 187-197... [Pg.227]

Figure 5.67 Reconstructed ion chromatograms for Idoxifene and internal standard (ds-Idoxifene using LC-ToF-MS for (a) double-blank human plasma extract, (b) extract of blank human plasma containing internal standard (IS), and (c) control-blank human plasma spiked with Idoxifene at 5 gml , the LOQ of the method. Reprinted from 7. Chromatogr., B, 757, Comparison between liquid chromatography-time-of-flight mass spectrometry and selected-reaction monitoring liquid chromatography-mass spectrometry for quantitative determination of Idoxifene in human plasma , Zhang, H. and Henion, J., 151-159, Copyright (2001), with permission from Elsevier Science. Figure 5.67 Reconstructed ion chromatograms for Idoxifene and internal standard (ds-Idoxifene using LC-ToF-MS for (a) double-blank human plasma extract, (b) extract of blank human plasma containing internal standard (IS), and (c) control-blank human plasma spiked with Idoxifene at 5 gml , the LOQ of the method. Reprinted from 7. Chromatogr., B, 757, Comparison between liquid chromatography-time-of-flight mass spectrometry and selected-reaction monitoring liquid chromatography-mass spectrometry for quantitative determination of Idoxifene in human plasma , Zhang, H. and Henion, J., 151-159, Copyright (2001), with permission from Elsevier Science.
Barcelo D. 1988. Application of thermospray liquid chromatography/mass spectrometry for determination of organophosphoms pesticides and trialkyl and triaryl phosphates. Biomed Environ Mass Spectrom 17 363-369. [Pg.194]

Camurri, G., Zaramella, A. High-throughput liquid chromatography/mass spectrometry method for the determination of the chromatographic hydrophobicity index. Anal. Chem. 2001,... [Pg.353]

Several methods can be used for the residue analysis of anilides, especially gas chro-matography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS). GC/ECD or GC/NPD for the determination of anilides has generally been used except for the unstable metabolites of naproanilide and clomeprop, which are determined by HPLC/UV, HPLC/FL or GC/ECD after derivatization. [Pg.332]

The method for chloroacetanilide soil metabolites in water determines concentrations of ethanesulfonic acid (ESA) and oxanilic acid (OXA) metabolites of alachlor, acetochlor, and metolachlor in surface water and groundwater samples by direct aqueous injection LC/MS/MS. After injection, compounds are separated by reversed-phase HPLC and introduced into the mass spectrometer with a TurboIonSpray atmospheric pressure ionization (API) interface. Using direct aqueous injection without prior SPE and/or concentration minimizes losses and greatly simplifies the analytical procedure. Standard addition experiments can be used to check for matrix effects. With multiple-reaction monitoring in the negative electrospray ionization mode, LC/MS/MS provides superior specificity and sensitivity compared with conventional liquid chromatography/mass spectrometry (LC/MS) or liquid chromatography/ultraviolet detection (LC/UV), and the need for a confirmatory method is eliminated. In summary,... [Pg.349]

The need to understand the fate of pesticides in the environment has necessitated the development of analytical methods for the determination of residues in environmental media. Adoption of methods utilizing instrumentation such as gas chro-matography/mass spectrometry (GC/MS), liquid chromatography/mass spectrometry (LC/MS), liquid chromatography/tandem mass spectrometry (LC/MS/MS), or enzyme-linked immunosorbent assay (ELISA) has allowed the detection of minute amounts of pesticides and their degradation products in environmental samples. Sample preparation techniques such as solid-phase extraction (SPE), accelerated solvent extraction (ASE), or solid-phase microextraction (SPME) have also been important in the development of more reliable and sensitive analytical methods. [Pg.605]

E. M. Thurman and C. Batian, Determination of atrazine and atrazine mercapture in drinking water samples and in urine using immunoaffinity SPE with positive ion spray HPLC/MS , Presented at the 15th Symposium on Liquid Chromatography/Mass Spectrometry, Montreux, Switzerland, November 9-10, 1998. [Pg.786]

Ethylenethiourea (ETU) is a toxic decomposition product/metabolite of alky-lenebis(dithiocarbamates). This compound could be generated during processing of treated crops at elevated temperature. Different chromatographic methods to determine the residue levels of ETU have been published. After extraction with methanol, clean-up on a Gas-Chrom S/alumina column and derivatization (alkylation) with bro-mobutane, ETU residues can be determined by GC with a flame photometric detector in the sulfur mode. Alternatively, ETU residues can also be determined by an HPLC method with UV detection at 240 nm or by liquid chromatography/mass spectrometry (LC/MS) or liquid chromatography/tandem mass spectrometry (LC/MS/MS) (molecular ion m/z 103). ... [Pg.1091]

Several determination methods such as GC, HPLC, gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS) are used for the analysis of neonicotinoid residues. The applications of GC/MS and LC/MS are of increasing importance. The application of HPLC to the determination of neonicotinoids residues is limited, especially when metabolites (such as acetamiprid and nitenpyram) can be easily determined by GC after derivatization. [Pg.1133]

Gas-chromatographic determination for plant materials liquid chromatography/mass spectrometric determination for water and soil... [Pg.1177]

S., Simultaneous determination of urinary cystathionine, lanthionine, S-(2-aminoethyl)-L-cysteine and their cyclic compounds using liquid chromatography-mass spectrometry with atmospheric pressure chemical ionization, /. Chromatogr. B, 698, 301, 1997. [Pg.305]

Andreu V, Ferrer E, Rubio JL, Font G, Pico Y (2007) Quantitative determination of octylphenol, nonylphenol, alkylphenol ethoxylates and alcohol ethoxylates by pressurized liquid extraction and liquid chromatography-mass spectrometry in soils treated with sewage sludges. Sci Total Environ 378 124—129... [Pg.103]

Bruno F, Curini A, Di Corcia A, Fochi I, Nazzari M, Samperi R (2002) Determination of surfactants and some of their metabolites in untreated and anaerobically digested sewage sludge by subcritical water extraction followed by liquid chromatography-mass spectrometry. Environ Sci Technol 36 4156—4161... [Pg.106]

Reversed phase liquid chromatography-mass spectrometry was applied to extracts of Jamaica Bay (New York) water to determine 1-300 xg/l amounts of nonyl phenol ethoxylates and their metabolites [213]. [Pg.403]

Ferrer and Barcelo [131] used online solid-phase-liquid chromatography mass spectrometry for the simultanous determination of organotin antifouling herbicides in marine water. The solid-phase extraction was carried out on polymeric cartridges after percolation of 100 ml of the seawater sample, and... [Pg.473]

Petrovic M, Lacorte S, Viana P, Barcelo D (2002) Pressurized liquid extraction followed by liquid chromatography-mass spectrometry for the determination of alkylphenolic compounds in river sediment. J Chromatogr A 959 15-23... [Pg.330]

Ferrer I. and Barcelo, D., 1999. Simultaneous determination of antifouling herbicides in marina water samples by online solid-phase extraction followed by liquid chromatography-mass spectrometry. J Chromatogr A 854 197. [Pg.294]

Lant M.S. and Oxford J., 1987. Automated sample preparation online with thermospray high-performance liquid chromatography-mass spectrometry for the determination of drugs in plasma. J Chromatogr A 394 223. [Pg.296]

Recent studies, including the use of Microtox and ToxAlert test kits [55,56], were carried out for the determination of the toxicity of some non-ionic surfactants and other compounds (aromatic hydrocarbons, endocrine disruptors) before implementation on raw and treated wastewater, followed by the identification and quantification of polar organic cytotoxic substances for samples with more than 20% inhibition. Furthermore, the study of their contribution to the total toxicity was obtained using sequential solid-phase extraction (SSPE) before liquid chromatography-mass spectrometry (LC-MS) detection. This combined procedure allows one to focus only on samples containing toxic substances. [Pg.263]

C. Soler, B. Hamilton, A. Furey, K. J. James, J. Manes, and Y. Pico. Comparison of Four Mass Analyzers for Determining Carbosulfan and Its Metabolites in Citrus by Liquid Chromatography/Mass Spectrometry. Rapid Commun. Mass Spectrom., 20(2006) 2151-2164. [Pg.102]

Liquid chromatography-mass spectrometry has been used to determine triazine pesticides in land-fill soils [18] and dioctadecylmethyl ammonium in sewage sludges [19, 20],... [Pg.56]

See other pages where Liquid chromatography—mass determination is mentioned: [Pg.187]    [Pg.286]    [Pg.282]    [Pg.223]    [Pg.354]    [Pg.419]    [Pg.388]    [Pg.80]    [Pg.388]    [Pg.401]    [Pg.621]    [Pg.724]    [Pg.734]    [Pg.1146]    [Pg.331]    [Pg.256]    [Pg.175]    [Pg.606]    [Pg.306]    [Pg.145]    [Pg.319]    [Pg.55]   
See also in sourсe #XX -- [ Pg.455 , Pg.459 , Pg.476 ]



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