Liquid chromatography with mass

What are the Advantages of Linking High Performance Liquid Chromatography with Mass Spectrometry ... [Pg.20]

Schroder, H.E (2003). Determination of fluorinated surfactants and their metabolites in sewage sludge samples by liquid chromatography with mass spectrometry and tandem mass spectrometry after pressurized liquid extraction and separation on fluorine-modified reversed-phase sorbents. J. Chromatogr. A 1020(1), 131-151. [Pg.445]

M. R. Guasch Jane, M. Ibem Gomez, C. Andres Lacueva, O. Jauregui and R. M. Lamuela Raventos, Liquid chromatography with mass spectrometry in tandem mode applied for the identification of wine markers in residues from ancient Egyptian vessels, Analytical Chemistry, 76, 1672 1677 (2004). [Pg.127]

Ayrton J. et al., 1998. Optimisation and routine use of generic ultra-high flow-rate liquid chromatography with mass spectrometric detection for the direct online analysis of pharmaceuticals in plasma. J Chromatogr A 8282 199. [Pg.293]

Fig. 19.10. Combining liquid chromatography with mass spectrometry involves a difficult courtship [38],...

R.C. Willoughby and R.F. Browner, Monodisperse aerosol generation interface for combining liquid chromatography with mass spectrometry, Anal. Chem., 56 (1984) 2625-2631. [Pg.751]

Willoughby, R.C. Browner, R.F. Mono-disperse Aerosol Generation Interface for Combining Liquid Chromatography with Mass Spectroscopy. Anal. Chem. 1984,56, 2625-2631. [Pg.221]

Abian, J. The Coupling of Gas and Liquid Chromatography With Mass Spectrometry. J. Mass Spectrom. 1999, 34, 157-168. [Pg.471]

While the first coupling of gas chromatography and mass spectrometry had been reported in the late fifties [4] one had to wait for almost another 20 years before the direct interfacing of liquid chromatography with mass spectrometry (LC-MS) was described by Arpino et al. [5]. With the direct liquid interface (DLI) the effluent of the chromatographic column was directly introduced in the electron impact source. Contrarily to gas chromatography coupled to mass spectrometry (GC-MS), LC-MS did do not catch on as rapidly. One of the reasons was that the MS interface could only handle LC fiow rates of a few microliters per minute. Another limitation was that electron impact or chemical ionization was not suit-... [Pg.3]

In atmospheric pressure ionization sources (API) the ions are first formed at atmospheric pressure and then transferred into the vacuum. In addition, some API sources are capable of ionizing neutral molecules in solution or in the gas phase prior to ion transfer to the mass spectrometer. Because no liquid is introduced into the mass spectrometer these sources are particularly attractive for the coupling of liquid chromatography with mass spectrometry. Pneumatically assisted electrospray (ESI), atmospheric pressure chemical ionization (APCI) or atmospheric pressure photoionization (APPI) are the most widely used techniques. [Pg.12]

Tiller, P. R. Romanyshyn, L. A. Implications of matrix effects in ultrafast gradient or fast isocratic liquid chromatography with mass spectrometry in drug discovery. Rapid Commun Mass Spectrom 2002, 16, 92-98. [Pg.425]

Whigan, D. Powell, M. L. Increased throughput in quantitative bioanalysis using parallel-column liquid chromatography with mass spectrometric detection. Rapid Commun Mass Spectrom 2001, 15,... [Pg.425]

The gas-liquid chromatography with mass spectrometric detection (GLC-MS) analysis of the electrolyzed solution has shown that thiophenol is the only reduction product and the S—S bond cleavage is quantitative. Such a mechanism of bond breaking was confirmed by electrochemical studies. In cyclic voltammograms, anodic and cathodic peak potentials were the same for thiophenol and diphenyl disulfides thus the same species were participating in these processes. Electrode reactions of diphenyl disulfide are given by the following equations [166] ... [Pg.861]

Coupling of liquid chromatography with mass spectrometry provides further unequivocal online spectrometric identification of individual analytes at the very low residue levels required by regulatory agencies for confirmatory analysis... [Pg.925]

Coupling of liquid chromatography with mass spectrometry allows unequivocal online spectrometric identification of all nitrofurans at the very low residue concentrations required by regulatory agencies for confirmatory analysis in animal-derived foods. Typical examples of mass spectrometry applications in confirming nitrofuran residues in edible animal products employ thermospray (174, 176), ionspray (166), or atmospheric pressure chemical ionization (157) interfaces. [Pg.948]

Coupling of liquid chromatography with mass spectrometry can provide unequivocal on-line spectrometric identification of anthelminthic residues in animal-derived foods. Typical applications of such techniques include the confirmation of moxidectin residues in cattle fat by liquid chromatography-thermospray mass spectrometry (352), and the confirmation of eprinomectin residues in bovine liver tissue by liquid chromatography, electrospray ionization, and multiple reaction monitoring in the MS-MS mode with positive ion detection (370). [Pg.1026]

The number of detectors that are sensitive and selective enough to be applied online with LC is limited because the solvents used are not compatible, as in the case of immunochemical detection after reversed- or normal-phase LC. The technology of coupling is still under development and not yet available in a large number of laboratories not specialized in techniques such as LC-MS. Therefore, LC separations are frequently followed by offline detection. Confirmatory analysis of suspected liquid chromatographic peaks can be made possible by coupling liquid chromatography with mass spectrometry. Atmospheric-pressure chemical ionization LC-MS has been employed for the identification of six steroid hormones in bovine tissues (448). [Pg.1065]

B. Ardrey, Liquid Chromatography-Mass Spectrometry An Introduction (Chichester, UK Wiley, 2003) W. M. A. Niessen. Liquid Chromatography-Mass Spectrometry, 2nd ed (New York Marcel Dekker, 1999) M. S. Lee, LC/MS Applications in Drug Development (New York Wiley, 2002) J. Abian, Historical Feature The Coupling of Gas and Liquid Chromatography with Mass Spectrometry, J. Mass Spectrom. 1999, 34, 157. [Pg.679]

Rosas, M.E., K.L. Preston, D.H. Epstein, E.T. Moolchan, et al., Quantitative determination of the enantiomers of methadone and its metabolite (EDDP) in human saliva by enantioselective liquid chromatography with mass spectrometric detection, J. Chromatogr. B Anal. Technol. Biomed. Life Sci., 796(2), 355-370, 2003. [Pg.59]

Vlase, L., Imre, S., Muntean, D., and Leucuta, S. E. (2007). Determination of loratadine and its active metabolite in human plasma by high-performance liquid chromatography with mass spectrometry detection. J. Pharm. Biomed. Anal. 44 652-657. [Pg.82]

High-performance liquid chromatography with mass spectrometry detection has been applied to the analysis of compounds such as azo dyes in wastewater, trace levels of pesticides in water, and picogram levels of... [Pg.106]

Itabashi, Y., Marai, L. and Kuksis, A. (1991) Identification of natural diacylglycerols as the 3,5-dinitrophenylurethanes by chiral phase liquid-chromatography with mass-spectrometry. Lipids, 26(11), 951-956. [Pg.91]