Tandem mass spectrometr

The ion spray liquid chromatography/mass spectrometry (LC-MS) interface coupled via a postsuppressor split with an ion chromatography (IC) has been used in the analysis of alcohol sulfates. The IC-MS readily produces the molecular weight while the tandem mass spectrometric detection IC-MS-MS provides structural information [305]. 

Figure 3.29 Structure of atrazine. Reprinted from J. Chromatogr., A, 915, Steen, R. J. C. A., Bobeldijk, I. and Brinkman, U. A. Th., Screening for transformation products of pesticides using tandem mass spectrometric scan modes , 129-137, Copyright (2001), with permission from Elsevier Science.

Herbach, K.M., Stintzing, E.C., and Carle, R., Thermal degradation of betacyanins in juices from purple pitaya (Hylocereus polyrhizus [Weber] Britton Rose) monitored by high-performance liquid-chromatography-tandem mass spectrometric analyses, Fur. Food Res. TechnoL, 219, 377, 2004. 

Wang, W. Liu, Z. Ma, L. Hao, C. Liu, S. Voinov, V. G. Kalinosvskaya, N. I. Electrospray ionization multiple-stage tandem mass spectrometric analysis of digycosyldiacylglycerol glycolipids from the bacteria Bacillus pumilus. Rapid Comm. Mass Spectrom. 1999,13,1189-1196. 

Prasain, JK, Moore, R, Hurst, JS, Barnes, S, and van Kuijk, F, 2005. Electrospray tandem mass spectrometric analysis of zeaxanthin and its oxidation products. J Mass Spectrom 40, 916-923. 

Matejicek D, Houserova P, Kuban V (2007) Combined isolation and purification procedures prior to the high-performance liquid chromatographic-ion-trap tandem mass spectrometric determination of estrogens and their conjugates in river sediments. J Chromatogr A 1171 (l-2) 80-89... 

High performance liquid chromatography-mass spectrometric methods Nitin et al. [75] developed and validated a sensitive and selective liquid chromatography-tandem mass spectrometric method (LC MS MS) for the simultaneous estimation of bulaquine and its metabolites primaquine in monkey plasma. The mobile phase consisted of acetonitrile ammonium acetate buffer (20 mM, pH 6) (50 50, v/v) at a flow rate of 1 mL/min. The chromatographic separations were achieved on two Spheri cyano columns (5 pm, 30 cm x 4.6 mm), connected in... 

Sanchez-Rabaneda F, Jauregui O, Casals I, Andres-Lacueva C, Izquierdo-Pulido M and Lamuela-Raventos RM. 2003. Liquid chromatographic/electrospray ionization tandem mass spectrometric study of the phenolic composition of cocoa (Theobroma cacao). J Mass Spectrom. 38(1) 35—42. 

Urpi-Sarda M, Zamora-Ros R, Lamuela-Raventos R, Cherubini A, Jauregui O, de la Torre R, Covas MI, Estruch R, Jaeger W and Andres-Lacueva C. 2007. HPLC-tandem mass spectrometric method to characterize resveratrol metabolism in humans. Clin Chem 53(2) 292-299. 

Tandem mass spectrometric methods have demonstrated superb specificity because of their ability to isolate analytes selectively in the presence of endogenous interferences. Attempts to further increase sample throughput led to the idea of using LC/MS/MS without the LC. Traditional chromatographic separations were replaced with flow injection analysis (FLA) or nanoelectrospray infusion techniques. The MS-based columnless methods attracted a lot of attention because of their inherent fast cycle times and no need for LC method development. 

Christiaens B. et al., 2004. Fully automated method for the liquid chromatographic-tandem mass spectrometric determination of cyproterone acetate in human plasma using restricted access material for online sample clean-up, J Chromatogr A 1056. 

Hogenboom A.C., Niessen W.M.A., and Brinkman U.A., 1999a. Online solid-phase extraction-short-column liquid chromatography combined with various tandem mass spectrometric scanning strategies for the rapid study of transformation of pesticides in surface water. J Chromatogr A 841 33. 

Schellen A. et al., 2000. High throughput online solid phase extraction/tandem mass spectrometric determination of paclitaxel in human serum. Rapid Commun Mass Spectrom 14 230. 

Wallemacq, P.E. et al. 2003. High-throughput liquid chromatography-tandem mass spectrometric analysis of sirolimus in whole blood. Clin Chem Lab Med. 41 921. 

C.W. Huck, M.R. Buchmeiser and G.K. Bonn, Fast analysis of flavonoids in plant extracts by liquid chromatography-ultraviolet absorbance detection on poly(carboxylic acid)coated silica and electrospray ionization tandem mass spectrometric detection. J. Chromatogr.A 943 (2002) 33-38. 

J. Wollgast, L. Pallaroni, M.-E. Agazzi and E. Anklam, Analysis of procyanidins in chocolate by reversed-phase high-performance liquid chromatography with electrospray ionisation mass spectrometric and tandem mass spectrometric detection. J. Chromatogr.A 926 (2001) 211-220. 

Cheng Y.F. Lu Z. Neuc U. Ultrafast liquid chromatography/ultraviolet and liquid chromatography/tandem mass spectrometric analysis. Rapid Communications in Mass Spectrometry, 2001, 15, 141-151. 

Romanyshyn L. Tiller P. Ultra-short columns and ballistic gradients considerations for ultra-fast chromatographic liquid chromatographic-tandem mass spectrometric analysis. Journal of Chromatography A, 2001,928,41-51. 

Bema M.J. Ackermann B.L. Murphy A.T. High-throughput chromatographic approaches to liquid chromatographic/tandem mass spectrometric bioanalysis to support drug discovery and development. Analytica ChimicaActa, 2004, 509, 1-9. 

Example Tandem mass spectrometric experiments in quadmpole ion traps are performed by combining the techniques of resonant ejection, and forward and reverse scanning to achieve an optimum in precursor ion selection, ion activation, and fragment ion scanning (Fig. 4.45). [156]... 

Fig. 4.45. Complex scan function used for a tandem mass spectrometric study of 2,4,3, 6 -tetrachlorodiphenylether. Reproduced from Ref. [156] by permission. lohn Wiley and Sons, 1997.

Yinon, J. Mass Spectral Fragm tation Pathways in Phtbalate Esters. A Tandem Mass Spectrometric Collision-Induced Dissociation Study. Org. Mass Spectrom. 1988,23,755-759. 

Enantioseparation of nine amphetamine derivatives, methorphan, and propoxyphene was studied by comparing two different CSP typologies, a macrocyclic antibiotic CSP (vancomycin) and a native P-cyclodextrin CSP [123]. The suitability of the eluent systems to ESI interfacing was discussed, and a tandem mass spectrometric (MS/MS) detection method was developed. 

Hows ME, Lacroix L, Heidbreder C, Organ AJ, Shah AJ. 2004. High-performance liquid chromatography/tandem mass spectrometric assay for the simultaneous measurement of dopamine, norepinephrine, 5-hydroxytryptamine and cocaine in biological samples. J Neurosci Methods 138 123. Hows ME, Organ AJ, Murray S, Dawson LA, Foxton R, et al. 

Moody DR, Laycock JD, Huang W, Foltz RL. 2004. A high-performance liquid chromatographic-atmospheric pressure chemical ionization-tandem mass spectrometric method for determination of risperidone and 9-hydroxyr-isperidone in human plasma. J Anal Toxicol 28 494. 

Murphey LJ, Hachey DL, Vaughan DE, Brown NJ, Morrow JD. 2001. Quantification of BKl-5, the stable bradykinin plasma metabolite in humans, by a highly accurate liquid chromatographic tandem mass spectrometric assay. Anal Biochem 292 87. 

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