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Liquid chromatography-mass tandem methods

High performance liquid chromatography-mass spectrometric methods Nitin et al. [75] developed and validated a sensitive and selective liquid chromatography-tandem mass spectrometric method (LC MS MS) for the simultaneous estimation of bulaquine and its metabolites primaquine in monkey plasma. The mobile phase consisted of acetonitrile ammonium acetate buffer (20 mM, pH 6) (50 50, v/v) at a flow rate of 1 mL/min. The chromatographic separations were achieved on two Spheri cyano columns (5 pm, 30 cm x 4.6 mm), connected in... [Pg.187]

Chi C, Liang L, Padovani P et al. (2003) Development and validation of a liquid chromatography-mass spectrometric method for the determination of DPC 423, an antithrombotic agent, in rat and dog plasma. J Chromatogr B Analyt Technol Biomed Life Sci 783( 1) 163—172 Zimmer D, Muschalek V, Muller C (2000) Determination of met-rifonate enantiomers in blood and brain samples using liquid chromatography on a chiral stationary phase coupled to tandem mass spectrometry. Rapid Commun Mass Spec-trom 14(15) 1425-1432... [Pg.605]

Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ (2008) Multiresidue methods for the analysis of pharmaceuticals, personal care products and illicit drugs in surface water and wastewater by solid-phase extraction and ultra performance liquid chromatography-electrospray tandem mass spectrometry. Anal Bioanal Chem 391(4) 1293-1308... [Pg.225]

More recently, liquid chromatography/mass spectrometry (LC/MS) and liquid chromatography/tandem mass spectrometry (LC/MS/MS) have been evaluated as possible alternative methods for carfentrazone-ethyl compounds in crop matrices. The LC/MS methods allow the chemical derivatization step for the acid metabolites to be avoided, reducing the analysis time. These new methods provide excellent sensitivity and method recovery for carfentrazone-ethyl. However, the final sample extracts, after being cleaned up extensively using three SPE cartridges, still exhibited ionization suppression due to the matrix background for the acid metabolites. Acceptable method recoveries (70-120%) of carfentrazone-ethyl metabolites have not yet been obtained. [Pg.488]

The need to understand the fate of pesticides in the environment has necessitated the development of analytical methods for the determination of residues in environmental media. Adoption of methods utilizing instrumentation such as gas chro-matography/mass spectrometry (GC/MS), liquid chromatography/mass spectrometry (LC/MS), liquid chromatography/tandem mass spectrometry (LC/MS/MS), or enzyme-linked immunosorbent assay (ELISA) has allowed the detection of minute amounts of pesticides and their degradation products in environmental samples. Sample preparation techniques such as solid-phase extraction (SPE), accelerated solvent extraction (ASE), or solid-phase microextraction (SPME) have also been important in the development of more reliable and sensitive analytical methods. [Pg.605]

Ethylenethiourea (ETU) is a toxic decomposition product/metabolite of alky-lenebis(dithiocarbamates). This compound could be generated during processing of treated crops at elevated temperature. Different chromatographic methods to determine the residue levels of ETU have been published. After extraction with methanol, clean-up on a Gas-Chrom S/alumina column and derivatization (alkylation) with bro-mobutane, ETU residues can be determined by GC with a flame photometric detector in the sulfur mode. Alternatively, ETU residues can also be determined by an HPLC method with UV detection at 240 nm or by liquid chromatography/mass spectrometry (LC/MS) or liquid chromatography/tandem mass spectrometry (LC/MS/MS) (molecular ion m/z 103). ... [Pg.1091]

F. Calbiani, M. Careri, L. Elviri, A. Mangia, L. Pistara and I. Zagnoni, Development and in-house validation of a liquid chromatography-electrospray-tandem mass spectrometry method for the simultaneous determination of Sudan I, Sudan II, Sudan II and Sudan IV in hot chili products. J. ChromatogrA, 1043 (2004) 123-130. [Pg.567]

Because of these ever-widening interests, the measurement of plasma tHcy is undertaken in many clinical chemistry and routine laboratories. Various methods are employed, including high-performance liquid chromatography (HPLC) assays, conventional amino acid analysis, capillary electrophoresis, gas chromatography with or without mass spectrometry, liquid chromatography with tandem mass spectrometry, and in many routine clinical chemistry laboratories immunoassays. In this chapter, those methods that are often available in laboratories involved in the investigation of inborn errors of metabolism are described, namely HPLC and tandem mass spectrometry. [Pg.93]

Tagliacozzi D, Mozzi AF, Casetta B, Bertucci P, Bernardini S, Di Ilio C, Urbani A, Federici G (2003) Quantitative analysis ofbile acids in human plasma by liquid chromatography-electrospray tandem mass spectrometry a simple and rapid one-step method. Clin Chem Lab Med 41 1633-1641... [Pg.663]

Dahn T, Gunn J, Kriger S, Terrell AR (2010) Quantitation of morphine, codeine, hydrocodone, hydromorphone, oxycodone, oxymorphone, and 6-monoacetylmorphine (6-MAM) in urine, blood, serum, or plasma using liquid chromatography with tandem mass spectrometry detection. Methods Mol Biol 603 411 122... [Pg.141]

As an instrumental approach to conventional electrophoresis, capillary electrophoresis offers the capability of on-line detection, micropreparative operation and automation (6,8,45-47). In addition, the in tandem connection of capillary electrophoresis to other spectroscopy techniques, such as mass spectrometry, provides high information content on many components of the simple or complex peptide under study. For example, it has been possible to separate and characterize various dynorphins by capillary electrophoresis-mass spectrometry (33). Therefore, the combination of CE-mass spectrometry (CE-MS) provides a valuable analytical tool useful for the fast identification and structural characterization of peptides. Recently, it has been demonstrated that the use of atmospheric pressure ionization using Ion Spray Liquid Chromatography/ Mass Spectrometry is well suited for CE/MS (48). This approach to CE/MS provides a very effective and straightforward method which allow the feasibility of obtaining CE/MS data for peptides from actual biological extracts, i.e., analysis of neuropeptides from equine cerebral spinal fluid (33). [Pg.7]

Loffler, D. and Temes, T.A. Analytical method for the determination of aminoglycoside gentamicin in hospital wastewater via liquid chromatography-electrospray tandem mass spectrometry. /. Chromatogr. A. 2003, 1000,583—588. [Pg.92]

Calbiani, F. et al. Validation of an ion-pair liquid chromatography-electrospray-tandem mass spectrometry method for the determination of heterocychc aromatic amines in meat-based infant foods. FoodAddit. Contam. 2007, 24, 833-841. [Pg.156]

Careri, M., Corradini, C., Elviri, L., Nicoletti, L, Zagnoni, I. (2004). Liquid Chromatography-Electrospray Tandem Mass Spectrometry of cA-resveratrol and trani-resveratrol Development, validation, and application of the method to red wine, grape, and winemaking byproducts. [Pg.522]

Goebel, C., Trout, G.J., Kazlasuskas, R. Rapid screening method for diuretics in doping control using automated solid phase extraction and liquid chromatography-electrospray tandem mass spectrometry. Anal Chim. Acta 502, 65-74 (2004)... [Pg.278]

Vecchione, G., Casetta, B., Tomaiuolo, M., Grandone, E., Margaglione, M. A rapid method for the quantification of the enantiomers of Warfarin, Phenprocoumon and Acenocoumarol by two-dimensional-enantioselective liquid chromatography/electrospray tandem mass spectrometry. J. Chromatogr. B 850, 507-514 (2007)... [Pg.279]

Jansson, C., Pihlstrom, T., Osterdahl, B.G. andMarkides, K.E. (2004) Anew multiresidue method for analysis of pesticides residues in fruit and vegetables using liquid chromatography with tandem mass spectrometric detection, J. Chromatogr. A., 1023(1), 93-104. [Pg.248]

Modern tHcy methods include enzyme immunoassays and chromatographic-based methods. In practice, immunoassays " are most often used for routine purposes (e.g., fluorescence polarization immunoassay IFPIA] as run on Abbott s IMx and AxSYM platforms) Chromatographic assays include amino acid analysis high-performance liquid chromatography (HPLC) with ultraviolet, fluorescence, or electrochemical detection ° " capillary electrophoresis with fluorescence detection gas chromatography-mass spectrometry (GC-MS) and liquid chromatography with tandem MS (MS-MS). [Pg.968]

Jemal, M. Huang, M. Mao, Y. Whigan, D. Schuster, A. Liquid Chromatography/Electrospray Tandem Mass Spectrometry Method for the Quantitation of Fosinoprilat in Human Serum using Automated 96-Well Solid-Phase Extraction for Sample Preparation, Rapid Commun. Mass Spectrom. 14(12), 1023-1028 (2000). [Pg.507]

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See also in sourсe #XX -- [ Pg.289 , Pg.345 ]



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