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Liquid chromatography mass spectrometry case study

Rouse, J. C., McClellan, J. E., Patel, H. K., Jankowski, M. A. and Porter, T. J. Top-down characterization of protein pharmaceuticals by liquid chromatography/mass spectrometry application to recombinant Factor IX comparability—A case study. Methods Mol. Biol. 308 435—460, 2005. Johnson, K. A., Paisley-Flango, K., Tangarone, B. S., Porter, T. J. and Rouse, J. C. Cation exchange-HPLC and mass spectrometry reveal C-terminal amidation of an IgGl heavy chain. Anal. Biochem. 360 75—83, 2007. [Pg.350]

The combination of chromatography/mass spectrometry with MS/MS methods can in fact markedly enhance the analytical performance of the identification of phenols. This was demonstrated in the case of hydroxy aromatic components in coal-derived liquids. The analytical performance can be further improved by using chemical derivatization, as also shown in an MS/MS study of some methylphenols and methylnaphthols. In the course of GC/MS/MS analytical studies on nonylphenol in biological tissues, derivatization proved to be favourable in an indirect way The El mass spectrum of nonylphenol... [Pg.319]

This review provides an up-to-date overview of the application of analytical procedures based on MS for the characterization of organic natural materials in archaeological and historical objects. Applications that feature the use of gas chromatography/mass spectrometry (GC/MS), Py-GC/MS, high performance liquid chromatography combined with mass spectrometry (HPLC/MS), and direct MS analysis such as matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), electrospray ionization mass spectrometry (ESI-MS), and direct exposure mass spectrometry (DE-MS) are sununarized to highlight the different information provided by each of the various analytical approaches. Case studies and examples are also presented and include a description of the molecular markers and of the molecular profiles that are used to identify the original materials. [Pg.798]

In most cases, the thermal decompositions lead to a coevolution of several materials, particularly when the backbone of the polymer is broken apart. Because of the mbcture of products generated, identification of the constituents could only be made through the use of spectral subtraction or when small molecules with simple infrared spectra, such as carbon monoxide, carbon dioxide, and hydrogen chloride were generated. In the study on polyacrylamide (2), the effluent was trapped in a gas collection tube immersed in liquid nitrogen and then separated and analyzed by GC/FT-IR and gas chromatography/mass spectrometry. [Pg.103]

Larger, P. J., Breda, M., Lraier, D., Hughes, H., and James, C. A. (2005). Ion-suppression effects in liquid chromatography-tandem mass spectrometry due to a formulation agent, a case study in drug discovery bioanalysis. J. Pharm. Biomed. Anal. 39 206-216. [Pg.119]


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