High performance liquid chromatography coupled with tandem mass

Qian, T., Jiang, Z.-H., and Cai, Z. (2006). High-performance liquid chromatography coupled with tandem mass spectrometry applied for metabolic study of ginsenoside Rbj on rat. Anal. Biochem. 352, 87-96. [Pg.92]

Schneider H, Ma L, Glatt H. 2003. Extractionless method for the determination of urinary caffeine metabolites using high-performance liquid chromatography coupled with tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 789 227. [Pg.175]

Superior sensitivity, efficiency, and specificity have made high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS), the predominant analytical technique for characterization and quantitative analysis of metabolites (Kostiainen et al., 2003 Ma et al., 2006 Prakash et al., 2007). Ion trap, triple-quadrupole, and quadmpole time-of-flight (Q-TOF) mass spectrometers are routinely used to profile and characterize metabolites in plasma and excreta (Ma et al., 2006). The combination of scan types and features available on mass spectrometers of different design (product ion, MS", neutral loss, precursor ion scans, accurate mass measurements) allows identification and characterization of putative and unexpected metabolites with or without little prior knowledge of biotransformation pathways of a given dmg molecule. [Pg.296]

HPLC-MS-MS High Performance Liquid Chromatography coupled with tandem Mass Spectrometry Ka acidic dissociation constant (pfCa = - log10 fCa)... [Pg.222]

HPLC-MS/MS High-performance liquid chromatography coupled with tandem mass spectrometry... [Pg.326]

Jemal M., Xia Y., and Whigan D.B., 1998. The use of high-flow high performance liquid chromatography coupled with positive and negative ion electrospray tandem mass spectrometry for quantitative bioanalysis via direct injection of the plasma/serum samples. Rapid Commun Mass Spectrom 12 1389. [Pg.295]

Abbara C, Bardot I, Cailleux A, Lallement G, Le Bouil A, Turcant A, Clair P, Diquet B (2008) High-performance liquid chromatography coupled with electrospray tandem mass spectrometry (LC/MS/MS) method for the simultaneous determination of diazepam, atropine and pralidoxime in human plasma. J Chromatogr B 874 42-50... [Pg.343]

H. Rosing, M. J. X. HUlebrand, J. M. Jimeno, A. Gomez, and P. Floriano, Quantitative determination of Eteinascidin 743 in human plasma by miniaturized high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry,/. Mass Spectrom. 33 (1998), 1134-1140. [Pg.344]

Jemal, M. Qing, Y. Whigan, D.B. The Use of High-Flow High Performance Liquid Chromatography Coupled with Positive and Negative Ion Electrospray Tandem Mass Spectrometry for Quantitative Bioanalysis via Direct Injection of the Plasma/Serum Samples, Rapid Commun. Mass Spectrom. 12, 1389-1399 (1998). [Pg.353]

Plum, A. and Rehorek, A. (2005) Strategies for continuous on-line high performance liquid chromatography coupled with diode array detection and electrospray tandem mass spectrometry for process monitoring of sulfonated azo dyes and their intermediates in anaerobic-aerobic bioreactors. J Chrom A, 1084 (1-2), 119-133. [Pg.249]

R. E. Calaf, M. Carrascal, E. Gelpi, and J. Abian, Quantitative analysis of mevino-linic acid in human plasma by high-performance liquid chromatography coupled with negative-ion electrospray tandem mass spectrometry. Rapid Commun. Mass Spectrom. 11, 75-80 (1997). [Pg.499]

Liu Y, Li J, He J, Abliz Z, Qu J, Yu S, Ma S, Liu J, Du D (2009) Identification of new trace triterpenoid saponins from the roots of Panax notoginseng by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom 23 667-679... [Pg.4083]

Bennett, P.K. Li, Y.T. Edom, R. Henion, J. Quantitative determination of Orlistat (tetrahydrolipo-statin, Ro 18-0647) in human plasma by high-performance liquid chromatography coupled with ion spray tandem mass spectrometry, J.Mass Spectrom., 1997, 32, 739-749. [Pg.475]

Tian, Q. et al., Screening for anthocyanins using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry with precursor-ion analysis, product-ion analysis, common-neutral-loss analysis, and selected reaction monitoring, J. Chromatogr. A, 1091, 72, 2005. [Pg.501]

Zell, M. Husser, C. Hopfgartner, G. Low picogram determination of Ro 48-6791 and its major metabolite, Ro 48-6792, in plasma with columnswitching microbore high-performance liquid chromatography coupled to ion spray tandem mass spectrometry. Rapid Commun. Mass Spectrom. 1997, 11, 1107-1114. [Pg.59]

EDCs in the environment are often analyzed using GC or LC based instrumental techniques. GC coupled with an electron capture detector (BCD), a nitrogen-phosphorus detector (NPD), or mass spectrometry (MS) has been the preferred method due to its excellent sensitivity and separation capability on a capillary column. High performance liquid chromatography (HPLC) with various detectors such as ultraviolet detection (UV), fluorescence detection (FLD), MS, and more recently tandem MS (MS/MS) has also been used for analysis of some EDCs, especially for the polar compounds. Analytical techniques for each class of EDCs will be discussed in the following section. [Pg.1249]

Kovalczuk et al. [81] developed a high-throughput method for multiresidue pesticide analysis in food matrices based on ultra high-performance liquid chromatography (UHPLC) with coupling to tandem mass spectrometry. Separation of 17 polar pesticides was achieved in under 8 min (see Figure 13.5). The authors compared UHPLC and conventional LC approaches, and they observed higher separation efficiencies with the LC method. Faster separations and better limits of quantitation were possible with the UHPLC method, however. A different approach for multiresidue... [Pg.350]

Gon9alves J.C.S. et al., 2005. Online solid-phase extraction coupled with high-performance liquid chromatography and tandem mass spectrometry (SPE HPLC-MS-MS) for quantification of bromazepam in human plasma. Ther Drug Monit 27 601. [Pg.294]

Raices R.S.L. et al., 2003. Determination of stavudine in human serum by online solid-phase extraction coupled to high-performance liquid chromatography with electrospray ionization tandem mass spectrometry Application to a bioequivalence study. Rapid Commun Mass Spectrom 17 1611. [Pg.296]