Liquid chromatography-atmospheric tandem mass spectrometry

See footnote cto Table3 LC/PB/MS = hquid chromatography/particle beam mass spectrometry LC/APcl/ESl-MS/MS = liquid chromtography/atmospheric pressure chemical ionization/electrospray ionization tandem mass spectrometry LC/FTIR = Fourier transform infrared LC/TSP-MS/MS = liquid chromatography/thermospray tandem mass spectrometry LC/TSP-MS = liquid chromatography/thermospray mass spectrometry. [Pg.423]

Liquid chromatography coupled to mass spectrometry and tandem mass spectrometry (LC/MS and LC/MS/MS) lead to major breakthroughs in the field of quantitative bioanalysis due to high specificity, sensitivity, speed, and reliability, which becomes the preferred analytical tools for analysis of drugs and metabolites in biological matrices. A simple and rapid method has been developed and validated for the quantitation of vincristine in human plasma by LC/MS/MS with atmospheric pressure chemical ionization using on-line solid-phase extraction. The method uses vinblastine as internal standard and the sample preparation is... [Pg.4331]

Specifically for triazines in water, multi-residue methods incorporating SPE and LC/MS/MS will soon be available that are capable of measuring numerous parent compounds and all their relevant degradates (including the hydroxytriazines) in one analysis. Continued increases in liquid chromatography/atmospheric pressure ionization tandem mass spectrometry (LC/API-MS/MS) sensitivity will lead to methods requiring no aqueous sample preparation at all, and portions of water samples will be injected directly into the LC column. The use of SPE and GC or LC coupled with MS and MS/MS systems will also be applied routinely to the analysis of more complex sample matrices such as soil and crop and animal tissues. However, the analyte(s) must first be removed from the sample matrix, and additional research is needed to develop more efficient extraction procedures. Increased selectivity during extraction also simplifies the sample purification requirements prior to injection. Certainly, miniaturization of all aspects of the analysis (sample extraction, purification, and instrumentation) will continue, and some of this may involve SEE, subcritical and microwave extraction, sonication, others or even combinations of these techniques for the initial isolation of the analyte(s) from the bulk of the sample matrix. [Pg.445]

Homish, R. E. and Wiest, J. R., Quantitation of spectinomycin residues in bovine tissues by ion-exchange high-performance liquid chromatography with post-column derivatization and confirmation by reversed-phase high performance chromatography-atmospheric pressure chemical ionization tandem mass spectrometry, /. Chromatogr. A, 812, 123, 1998. [Pg.312]

For confirmatory assay, liquid chromatography-tandem mass spectrometry (LC-MS/MS) is becoming more frequently used in the analysis of OTC owing to its high sensitivity and ability. Electrospray ionization (ESI) [55-57] and atmospheric pressure chemical ionization (APCI) [41] methods combined with tandem mass spectrometry are favored because of their higher sensitivity and better reproducibility. Hamscher et al. [58] developed a method for the determination of persistent TC residues in soil fertilized with manure by HPLC tandem mass spectrometry, MS-MS, and confirmation by MS-MS-MS. Zhu et al. [59] developed an LC-tandem mass spectrometry for the analysis of common tetracyclines in water. The detection limit for oxytetracycline was 0.21 pg/L. Lykkeberg et al. [60] used LC-MS/MS for determination of oxytetracycline and its impurities EOTC, TC, ETC, ADOTC, oc-AOTC, and /i-AOTC. [Pg.111]

G.A. van der Doelen, K.J. van den Berg, J.J. Boon, N. Shibayama, E.R. de la Rie, W.J.L. Genuit, Analysis of fresh triterpenoid resins and aged triterpenoid varnishes by high performance liquid chromatography atmospheric pressure chemical ionisation (tandem) mass spectrometry, Journal of Chromatography A, 809, 21 37 (1998). [Pg.33]

Beaudry F. et al., 1998. In vivo pharmacokinetic screening in cassette dosing experiments Use of online Pros-pekt liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry technology in drug discovery. Rapid Commun Mass Spectrom 12 1216. [Pg.293]

Karlsson AA, Michelsen P, Odham G. 1998. Molecular species of sphingomyelin determination by high-performance liquid chromatography/mass spectrometry with electrospray and high-performance liquid chromatography/tandem mass spectrometry with atmospheric pressure chemical ionization. J Mass Spectrom 33 1192. [Pg.171]

Prokai L, Zharikova AD, Janaky T, Prokai-Tatrai K. 2000. Exploratory pharmacokinetics and brain distribution study of a neuropeptide FF antagonist by liquid chromatography/atmospheric pressure ionization tandem mass spectrometry. Rapid Commun Mass Spectrom 14 2412. [Pg.174]

Xu AS, Peng LL, Havel JA, Petersen ME, Fiene JA, et al. 1996. Determination of nicotine and cotinine in human plasma by liquid chromatography-tandem mass spectrometry with atmospheric-pressure chemical ionization interface. J Chromatogr B Biomed Appl 682 249. [Pg.176]

X. Xu, A.M. van der Craats, E.M. Kok and P.C.A.M. de Bruyn, Trace analysis of peroxide explosives by high performance liquid chromatography — atmospheric pressure chemical ionization — tandem mass spectrometry (HPLC-APCl-MS/MS) for forensic applications ,... [Pg.243]

Liang, H.R. Foltz, R.L. Meng, M. Bennett, P. Ionization enhancement in atmospheric pressure chemical ionization and suppression in electrospray ionization between target drugs and stable-isotope-labeled internal standards in quantitative liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2003, 17, 2815—2821. [Pg.372]

C. Nomeir, A. A. Validation of higher-throughput high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry assays to conduct cytochrome P450s CYP2D6 and CYP3A4 enzyme inhibition studies in human liver microsomes. Rapid Commun Mass Spectrom 2000, 14, 207-214. [Pg.423]

Fredline VF, Taylor PJ, Dodds HM, Johnson AG (1997) A reference method for the analysis of aldosterone in blood by high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. Anal Biochem 252 308-313... [Pg.601]

Guo T, Chan M, Soldin SJ (2004) Steroid profiles using liquid chromatography-tandem mass spectrometry with atmospheric pressure photoionization source. Arch Path Lab Med 128 469-475... [Pg.601]

DR Doerge, S Bajic. Multiresidue determination of quinolone antibiotics using liquid chromatography coupled to atmospheric-pressure chemical ionization mass spectrometry and tandem mass spectrometry. Rapid Commun Mass Spectrom 9 1012-1016, 1995. [Pg.690]

Kamel, A., and Prakash, C. (2006). High performance liquid chromatography/atmospheric pressure ionization/tandem mass spectrometry (HPLC/API/MS/MS) in drug metabolism and toxicology. Curr. Drug. Metab. 7 837-852. [Pg.187]

Stenhoff et al. [117] determined enantiomers of omeprazole in blood plasma by normal-phase liquid chromatography and detection by atmospheric-pressure ionization tandem mass spectrometry. The enantioselec-tive assay of omeprazole is using normal-phase liquid chromatography on a Chiralpak AD column and detection by mass spectrometry. Omeprazole is extracted by a mixture of dichloromethane and hexane and, after evaporation, redissolution and injection, separated into its enantiomers on the chiral stationary phase. Detection is made by a triple quadrupole mass spectrometer, using deuterated analogs and internal standards. The method enables determination in plasma down to 10 nmol/1 and shows excellent consistency suited for pharmacokinetic studies in man. [Pg.232]

C. C. 1997. Pharmacokinetic screening for the selection of new drug discovery candidates is greatly enhanced through the use of liquid chromatography-atmospheric pressure ionization tandem mass spectrometry. J. Chromatogr. A, 777,61-66. [Pg.208]

It also was reported by Lagerstroem et al that pantoprazole and its enantiomers can be separated by using normal-phase liquid chromatography, and detection by atmospheric pressure ionization tandem mass spectrometry [13]. [Pg.250]

In recent years the rapid development of high-sensitivity analytical techniques such as mass spectrometry (MS) and liquid chromatography (LC) supported the investigation of the endocannabinoids as part of a complex lipid network. The identification of lipid components of the endocannabinoid system can be achieved in a single analytical step by state-of-the-art platforms such as tandem mass spectrometry (MS/MS), which provides the detailed structural information necessary for characterization of lipids and increases specificity in complex biological matrices. Furthermore, the implementation of ionization techniques such as electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) allow the coupling of LC to MS, and permits the separation and analysis of endocannabinoids with greater speed and accuracy. [Pg.40]

Senthamil Selvan P, Gowda KV, Mandal U et al (2007) Determination of duloxetine in human plasma by liquid chromatography with atmospheric pressure ionization-tandem mass spectrometry and its application to pharmacokinetic study. J Chromatogr B Anal Technol Biomed Life Sci 858 269-275... [Pg.172]

Theron HB, van der Merwe MJ, Swart KJ et al (2007) Employing atmospheric pressure photoionization in liquid chromatography/tandem mass spectrometry to minimize ion suppression and matrix effects for the quantification of venlafaxine and O-desmethylvenlafaxine. Rapid Commun Mass Spectrom 21 1680-1686... [Pg.173]

Hsu J, Chang Y, Chen T, Lin L, Liao P (2007) Evaluation of electrospray ionization and atmospheric pressure chemical ionization for simultaneous detection of estrone and its metabolites using high-performance liquid chromatography/tandem mass spectrometry. J Chromatogr B 860 49-56... [Pg.280]

Lien G, Chen C, Wang G (2009) Comparison of electrospray ionization, atmospheric pressure chemical ionization and atmospheric pressure photoionization for determining estrogenic chemicals in water by liquid chromatography tandem mass spectrometry with chemical derivatizations. J Chromatogr A 1216 956-966... [Pg.283]

R.M. Black and R.W. Read, Application of liquid chromatography-atmospheric pressure chemical ionisation mass spectrometry and tandem mass spectrometry to the analysis and identification of degradation products of chemical warfare agents, J. Chromatogr. A, 759, 79-92 (1997). [Pg.181]