Liquid chromatography tandem mass spectrometry methodology

Plumb RS, Potts WB 3rd, RainviUe PD, Alden PG, Shave DH, Baynham G, Mazzeo JR. Addressing the analytical throughput challenges in ADME screening using rapid ultra-performance liquid chromatography/tandem mass spectrometry methodologies. Rapid Commun Mass Spectrom 2008 22(14) 2139—2152. 

Gros M, Petrovic M, Barcelo D (2006) Development of a multi-residue analytical methodology based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for screening and trace level determination of pharmaceuticals in surface and wastewaters. Talanta 70 678-690... 

Mastovska K, Lightfleld AR, Streamlining methodology for the multi-residue analysis of fi-lactam antibiotics in bovine kidney using liquid chromatography-tandem mass spectrometry, J. Chromatogr. A 2008 1202 118-123. 

Mastovska MK, Lightheld AR. Sheamlining methodology for the mulHresidue analysis of P-lactam antibiohcs in bovine kidney using liquid chromatography—tandem mass spectrometry. J Chromatogr A 2008 1202 118—23. 

Several methodologies have been published for the determination of selected emerging contaminants in sewage sludge. The most recently reported methods are summarized in Table 1, comprising extraction of the sludge sample, subsequent purification of the extract, and final analysis by either gas or liquid chromatography (GC or LC) coupled to mass spectrometry (MS) or tandem mass spectrometry (MS-MS). 

Bosch et al. [180] reviewed the analytical methodologies that have been used for the determination of omeprazole. The drug has been determined in formulation and in biological fluids by a variety of methods such as spectrophotometry, HPLC with UV detection, and liquid chromatography coupled with tandem mass spectrometry. The overview includes most relevant analytical methodologies used for the determination of the drug since the origin. 

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