High performance liquid chromatography combined with mass spectrometry

Explores strategies for optimizing techniques such as high-performance liquid chromatography combined with mass spectrometry (HPLC-MS) or tandem mass spectrometry (HPLC-MS-MS)... [Pg.415]

This review provides an up-to-date overview of the application of analytical procedures based on MS for the characterization of organic natural materials in archaeological and historical objects. Applications that feature the use of gas chromatography/mass spectrometry (GC/MS), Py-GC/MS, high performance liquid chromatography combined with mass spectrometry (HPLC/MS), and direct MS analysis such as matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), electrospray ionization mass spectrometry (ESI-MS), and direct exposure mass spectrometry (DE-MS) are sununarized to highlight the different information provided by each of the various analytical approaches. Case studies and examples are also presented and include a description of the molecular markers and of the molecular profiles that are used to identify the original materials. [Pg.798]

Reversed-phase high-performance liquid chromatography Scoville heat unit Solid-phase micro extraction Ultrasound-assisted extraction Ultra-high-performance liquid chromatography Ultra-performance liquid chromatography combined with mass spectrometry Ultraviolet... [Pg.106]

In the first chapter, I have discussed the limitations of high performance liquid chromatography (HPLC) and mass spectrometry when used in isolation and how the combination of the two allows these to be overcome. In this chapter, the effect of combining the two techniques with regard to the individual performance characteristics are explored. [Pg.11]

Q-ToF-LC-MS-MS quadrupole time-of-flight mass analyser in combination with (high performance) liquid chromatography and tandem mass spectrometry... [Pg.16]

Zell M., Husser C., and Hopfgartner G., 1997b. Column-switching high-performance liquid chromatography combined with ionspray tandem mass spectrometry for the simultaneous determination of the platelet inhibitor Ro 44-3888 and its pro-drug and precursor metabolite in plasma. J Mass Spectrom 32 23. [Pg.297]

Hop, C. E., Tiller, P. R., and Romanyshyn, L. (2002). In vitro metabolite identification using fast gradient high performance liquid chromatography combined with tandem mass spectrometry. Rapid Commun. Mass Spectrom. 16 212-219. [Pg.70]

Taylor SD, Wright B, Clayton E, Wilson ID, Practical aspects of the use of high performance liquid chromatography combined with simultaneous Nuclear Magnetic Resonance and Mass Spectrometry, Rapid Commun. Mass Spectrom., 12 1732-1736, 1998. [Pg.310]

C. M. Bruins, A.P. Compositional analysis of nitrile terminated poly(propylene imine) dendrimers by high-performance liquid chromatography combined with electrospray mass spectrometry. J. Chromatogr. A 1998, 825, 135-147. [Pg.887]

Zell, M. Husser, C. Hopfgartner, G. Column-Switching High-Performance Liquid Chromatography Combined with lonspray Tandem Mass Spectrometry for the Simultaneous Determination of the Platelet Inhibitor Ro 44-3888 and Its Pro-Drug and Precursor Metabolite in Plasma, J. Mass Spectrom. 32, 23-32 (1997). [Pg.352]

Hop, C.E. Tiller, PR. Romanyshyn, L. In Vitro Metabolite Identification Using Fast Gradient High Performance Liquid Chromatography Combined with Tandem Mass Spectrometry, Rapid Commun. Mass Spectrom. 16(3), 212-219 (2002). [Pg.374]

Imoto et al. by high performance liquid chromatography combined with atmospheric pressure ionisation mass spectrometry (API-MS). The crude saponin isolated from the leaves was chromatographed on octadecyl silica column and eluted with an aqueous methanol solution containing ammonium acetate. The fractions thus separated were directly introduced into an atmospheric pressure ionisation mass spectrometer connected with the liquid chromatograph by an interface consisting of a nebulizer and a vaporizer through a PTFE tube (Hitachi, Japan). The vaporized sample and solvent molecules at 300°C were introduced into the ion source of the atmospheric pressure ionisation system. [Pg.654]

Cherlet M, Baere SD, Backer PD, Determination of gentamicin in swine and calf tissues by high-performance liquid chromatography combined with electrospray ionization mass spectrometry, J. Mass Spectrom. 2000 35 1342-1350. [Pg.104]

Cherlet M, ScheUcens M, Croubels S, De Backer P, Quantitative multi-residue analysis of tetracyclines and their 4-epimers in pig tissues by high-performance liquid chromatography combined with positive ion electrospray ionization mass spectrometry, Anal. Chim. Acta 2003 492 199-213. [Pg.260]

Axelsson BO, Jornten-Karlsson M, Michelsen P, Abou-Shakra F. The potential of inductively coupled plasma mass spectrometry detection for high-performance liquid chromatography combined with accurate mass measurement of organic pharmaceutical compounds. Rapid Commun Mass Spectrom 2001 15 375-385. [Pg.359]

Dye C, Yttri KE (2005) Determination of monosaccharide anhydrides in atmospheric aerosols by use of high-performance liquid chromatography combined with high-resolution mass spectrometry. Anal Chem 77 1853-1858... [Pg.104]

GC-EAD Gas chromatography combined with an EAG detector GC-MS Gas chromatography combined with mass spectrometry HPLC High performance liquid chromatography KI Kovats retention index... [Pg.56]

Superior sensitivity, efficiency, and specificity have made high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS), the predominant analytical technique for characterization and quantitative analysis of metabolites (Kostiainen et al., 2003 Ma et al., 2006 Prakash et al., 2007). Ion trap, triple-quadrupole, and quadmpole time-of-flight (Q-TOF) mass spectrometers are routinely used to profile and characterize metabolites in plasma and excreta (Ma et al., 2006). The combination of scan types and features available on mass spectrometers of different design (product ion, MS", neutral loss, precursor ion scans, accurate mass measurements) allows identification and characterization of putative and unexpected metabolites with or without little prior knowledge of biotransformation pathways of a given dmg molecule. [Pg.296]

For off-bead analysis, coupling between chromatographic separation and mass spectrometric detection has proven especially powerful. The combination between high performance liquid chromatography (HPLC) and electrospray ionisation mass spectrometry has the advantage that purity of product mixtures can be coupled on-line with the product identification. [Pg.383]