Liquid chromatography-inductively coupled plasma mass detection

Garcia, S.D., Montes-Bayon, M., Blanco, G.E., Sanz-Medel, A. Speciation studies of cis-platin adducts with DNA nucleotides via elemental specific detection (P and Pt) using liquid chromatography-inductively coupled plasma-mass spectrometry and structural characterization by electrospray mass spectrometry. J. Anal. At. Spectrom. 21, 861-868 (2006)... 

The concentrations of the three arsenicals (75-77) were determined in 37 marine organisms comprising algae, crustaceans, bivalves, fish and mammals by high-performance liquid chromatography/inductively coupled plasma mass spectrometry (HPLC/ICPMS) [170]. All three organoarsenics, which occurred at pg/kg concentrations, were detected in 25, 23 and 17 of the 37 samples analyzed, respectively. The limits of detection were 2-3 pg/kg dry mass. The data illustrate that all three compounds are common minor constituents in practically all marine samples. 

Jensen Berit P, Smith C, Wilson ID, Weidolf L. Sensitive sulphur-specific detection of omeprazole metabolites in rat urine by high-performance liquid chromatography/ inductively coupled plasma mass spectrometry. Rapid Commun Mass Spectrom 2004 18 181-183. 

Figure 6 Schematic diagram of online coupling LC-ICP-MS via conventional nebulization and via microwave (MW)-HG. (Reprinted from Gonzalez LaFuente JM, Marchante Gayon JM, Fernandez Sanchez ML, and Sanz-Medel A (1999) Urinary selenium speciation by high-performance liquid chromatography-inductively coupled plasma mass spectrometry advantages of detection with a double focussing mass analyser with a hydride generation interface. Talanta 50 207-217.)...

A range of chromatographic techniques coupled to element specific detectors has been used in speciation studies to separate individual organometallic species (e.g., butyltins, arsenic species) and to separate metals bovmd to various biomolecules. The combination of a chromatographic separation with varying instrumental detection systems are commonly called coupled, hybrid, or hyphenated techniques (e.g., liquid chromatography inductively coupled plasma-mass spectrometry (LC-ICP-MS), gas chromatography-atomic absorption spectroscopy (GC-AAS)). The detection systems used in coupled techniques include MS, ICP-MS, atomic fluorescence spectrometry (AFS), AAS, ICP-atomic emission spectrometry (ICP-AES), and atomic emission detection (AED). 

LC-MS/MS and liquid chromatography-inductively coupled plasma mass spectrometry (LC-ICP-MS) have been used to detect CWA degradation products in beverages and food, respectively [35-37]. ICP-MS is used... 

In modern times, most analyses are performed on an analytical instrument for, e.g., gas chromatography (GC), high-performance liquid chromatography (HPLC), ultra-violet/visible (UV) or infrared (IR) spectrophotometry, atomic absorption spectrometry, inductively coupled plasma mass spectrometry (ICP-MS), mass spectrometry. Each of these instruments has a limitation on the amount of an analyte that they can detect. This limitation can be expressed as the IDL, which may be defined as the smallest amount of an analyte that can be reliably detected or differentiated from the background on an instrument. 

Zheng, J., Kosmus, W., Pichler-Semmelrock, F., and Kock, M., Arsenic speci-ation in human urine reference materials using high-performance liquid chromatography with inductively coupled plasma mass spectrometric detection, /. Trace Elements Med. Biol., 13, 150, 1999. 

R. Trones, Development of Packed Capillary High Temperature Liquid Chromatography Utilizing Light Scattering and Inductively Coupled Plasma Mass Spectrometry Detection, PhD. Thesis, University of Oslo (1999). 

Techniques for analysis of different mercury species in biological samples and abiotic materials include atomic absorption, cold vapor atomic fluorescence spectrometry, gas-liquid chromatography with electron capture detection, and inductively coupled plasma mass spectrometry (Lansens etal. 1991 Schintu etal. 1992 Porcella etal. 1995). Methylmercury concentrations in marine biological tissues are detected at concentrations as low as 10 pg Hg/kg tissue using graphite furnace sample preparation techniques and atomic absorption spectrometry (Schintu et al. 1992). 

Yang et al. [83] accomplished speciation of organotin compounds using reverse-phase liquid chromatography with inductively coupled plasma mass spectrometric detection. The separation was complete in 6min and detection limits were in the range 2.8-16pg of tin for various species. 

Corcoran, O., Nicholson, J. K., Lenz, E. M., Abou-Shakra, F., Castro-Perez, J., Sage, A. B., and Wilson, I. D. (2000). Directly coupled liquid chromatography with inductively coupled plasma mass spectrometry and orthogonal acceleration time-of-flight mass spectrometry for the identification of drug metabolites in urine Application to diclofenac using chlorine and sulfur detection. Rapid Commun. Mass Spectrom. 14 2377-2384. 

Thompson, J. J. and Houk, R. S., Inductively coupled plasma mass spectrometric detection for multielement flow injection analysis and elemental speciation by reversed phase liquid chromatography, Anal. Chem., 58, 2541-2548, 1986. 

Fairman, B., SanzMedel, A., Jones, P. and Evans, E.H. (1998) Comparison of fluorimetric and inductively coupled plasma mass spectrometry detection systems for the determination of aluminium species in waters by high-performance liquid chromatography. Analyst, 123, 699-703. 

Hansen, S.H., Larsen, E.H., Pritzi, G. and Cornett, C. (1992) Separation of seven arsenic compounds by high performance liquid chromatography with on-line detection by hydrogen-argon flame atomic absorption spectrometry and inductively coupled plasma mass spectrometry./. Anal. At. Spectrom., 1, 629-634. 

Figure 6.1 Bar-graph of MeHg in CRM 580. The results correspond to six replicate determinations as performed by different laboratories using various methods. MEANS indicates the mean of laboratory means with 95% confidence interval. Abbreviations-. CVAAS, cold vapour atomic absorption spectrometry CVAFS, cold vapour atomic fluorescence spectrometry ECD, electron capture detection GC, gas chromatography HPLC, high-performance liquid chromatography ICPMS, inductively coupled plasma mass spectrometry MIP, microwave induced plasma atomic emission spectrometry QFAAS, quartz furnace atomic absorption spectrometry SFE, supercritical fluid extraction.

Bushee, D.S. (1988) Speciation of mercury using liquid chromatography with detection by inductively coupled plasma mass spectrometry. Analyst, 113, 1167-1170. 

Evans, E. H. Wolff, J.-C. Eckers, C. 2001. Sulfur-specific detection of impurities in cimetidine drug substance using liquid chromatography coupled to high resolution inductively coupled plasma mass spectrometry and electrospray mass spectrometry. Anal. Chem., 73,4722-4728. 

E. H. Larsen, G. Pritzl, S. H. Hansen, Arsenic speciation in seafood samples with emphasis on minor constituents an investigation using high-performance liquid chromatography with detection by inductively coupled plasma mass spectrometry, J. Anal. Atom. Spectrom., 8 (1993), 1075-1084. 

S. Mounicou, J. Szpunar, R. Lobinski, D. Andrey, C. J. Blake, Bioavailability of cadmium and lead in cocoa comparison of extraction procedures prior to size-exclusion fast-Bow liquid chromatography with inductively coupled plasma mass spectrometric detection (SEC-ICP-MS), J. Anal. Atom. Spectrom., 17 (2002), 880D886. 

J. Zheng, M. Ohata, N. Furuta, W. Kosmus, Speciation of selenium compounds with ion-pair reversed-phase liquid chromatography using inductively coupled plasma mass spectrometry as element-specific detection. J. Chromatogr. A, 874 (2000), 55-64. 

X. C. Le, X. F. Li, V. Lai, M. Ma, S. Yalcin, J. Feldmann, Simultaneous speciation of selenium and arsenic using elevated temperature liquid chromatography separation with inductively coupled plasma mass spectrometry detection, Spectrochim. Acta, 53B (1998), 899-909. 

F. Li, W. Goessler, K. J. Irgolic, Determination of trimethylselenonium iodide, selenomethionine, selenious acid and selenic acid using high performance liquid chromatography with on-line detection by inductively coupled plasma mass spectrometry or flame atomic absorption spectrometry, J. Chromatogr. A, 830 (1999), 337-344. 

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